目的：在临床实践中很少遇到抗高尔基抗体（AGA），并且经常被认为与自身免疫性疾病有关。本研究旨在研究中国人群中AGA的患病率和临床意义。
方法：回顾性分析了2012年6月至2017年6月温岭市第一人民医院连续收集的间接免疫荧光（IIF）检测到的22,619例AGA的实验室报告。对8例AGA患者进行了相关临床和实验室特征的随访。
结果：共收集了22,619份实验室报告。在19例AGA患者中，7例（均为女性）患有自身免疫性疾病（AID），12例（6名女性和6名男性）患有非AID。AID患者中持续存在1:1000至1:3200的高滴度AGA，而在非AID患者中，从1:100到1:320的低滴度AGA是短暂的。
结论：这是首次评估住院中国人群AGA阳性率和相关临床表现的研究。AGA是罕见的，发生在多种疾病中。他们在AID中持续呈强烈阳性，而在非AID中低滴度和瞬时。
OBJECTIVE: Anti-golgi antibodies (AGAs) are rarely encountered and often considered in relation to autoimmune diseases in clinical practice. This research was performed for studying the prevalence and clinical significance of AGAs in Chinese population.
METHODS: We retrospectively reviewed 22,619 laboratory reports of AGAs detected by indirect immunofluorescence (IIF) were consecutively collected from the First People\'s Hospital of Wenling between June 2012 and June 2017. Eight patients with AGAs were followed up for relevant clinical and laboratory characteristics.
RESULTS: A total of 22,619 laboratory reports were collected. Of 19 patients with AGAs, 7 cases (all females) had autoimmune diseases (AID) and 12 cases (6 females and 6 males) had non-AID. High titer AGAs ranging from 1:1000 to 1:3200 were persistently present in AID patients, while low-titer AGAs ranging from 1:100 to 1:320 were transient in non-AID patients.
CONCLUSIONS: This is the first study to assess the AGA positive rate and relevant clinical manifestations in a hospitalized Chinese population. AGAs were rare and occurred in a variety of diseases. They were persistently strongly positive in AID, whereas low-titered and transient in non-AID.
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