血管内大B细胞淋巴瘤(IVLBCL)是一种罕见的影响大脑的淋巴瘤,皮肤,还有骨髓.我们描述了一名75岁男子在胃痛4小时后入院的情况。彻底的体格检查表明胃部不适和皮肤变色。实验室检查显示血小板减少和乳酸脱氢酶水平升高。腹部计算机断层扫描显示小肠壁增厚,水肿,和坏死。手术切除了坏死的小肠,露出许多小圆,同质,和肠系膜静脉的不寻常细胞.原位杂交显示这些细胞对PAX5、CD20、CD79a、CD10和BCL2,以及EB病毒编码的小RNA。住院1周后不治疗,患者被诊断为IVLBCL,死于多器官功能障碍综合征.IVLBCL是一种罕见的疾病,影响小肠和可能的胃肠道系统。它有一个阴险的开始,快速发展,预后不佳。了解其临床病理特征有助于了解疾病,做出早期诊断,防止快速恶化。
Intravascular large B-cell lymphoma (IVLBCL) is a rare lymphoma that affects the brain, skin, and bone marrow. We describe the case of a 75-year-old man who was admitted to the hospital after 4 h of stomach aches. A thorough physical examination indicated stomach discomfort and skin discoloration. Laboratory tests revealed thrombocytopenia and elevated lactate dehydrogenase levels. A computed tomography scan of the abdomen revealed that the small intestine wall was thickened, edematous, and necrotic. The necrotic small bowel was surgically removed, revealing many little round, homogenous, and unusual cells in the mesenteric vein. In-situ hybridization revealed that these cells were positive for PAX5, CD20, CD79a, CD10, and BCL2, as well as Epstein-Barr virus-encoded small RNA. After 1 week of hospitalization without treatment, the patient was diagnosed with IVLBCL and died of multiple organ dysfunction syndrome. IVLBCL is a rare illness that affects the small intestine and possibly the gastrointestinal system. It has an insidious start, a fast development, and a dismal prognosis. Knowing its clinicopathologic traits helps in understanding the illness, making an early diagnosis, and preventing rapid worsening.