轴后肢体发育不全(PALH)是一组影响腓骨射线的先天性下肢缺陷的非遗传性疾病,包括腓骨半乳,股骨近端局灶性缺陷,和tarsal联盟。该异常的病因和发育生物学仍未完全了解。这里,我们回顾了以前的分类系统,呈现临床特征,并讨论了PALH的发育生物学。
Postaxial limb hypoplasia (PALH) is a group of nonhereditary diseases with congenital lower limb deficiency affecting the fibular ray, including fibular hemimelia, proximal femoral focal deficiency, and tarsal coalition. The etiology and the developmental biology of the anomaly are still not fully understood. Here, we review the previous classification systems, present the clinical features, and discuss the developmental biology of PALH.