产前定量评估髓鞘很重要。然而,很少有技术适用于胎儿髓鞘形成的定量评估。
优化用于胎儿脑发育研究的改良Look-Locker反转恢复(MOLLI)T1映射序列。
前瞻性观察性初步队列研究。
共有71名正常胎儿的妇女被分为妊娠中期(胎龄24-28周,N=25)和妊娠晚期(胎龄>28周,N=46)组。
3T/MOLLI序列。
T1值在小脑中测量,基底神经节,丘脑,内囊的后肢,颞叶白质,枕骨白质,额叶白质,和顶叶白质由两名放射科医生(11年和16年的经验,分别)。
Kruskal-Wallis检验用于常规比较。对于每个感兴趣区域(ROI),通过MannWhitneyU检验评估妊娠中期和晚期组之间T1值的差异.使用皮尔逊相关系数(r)评估每个ROI的T1值与胎龄之间的相关性。观察者内部和观察者之间的一致性由类内相关系数(ICC)确定。P值<0.05被认为是统计学上显著的。
T1的观察者间和观察者间协议对所有ROI都很好(所有ICC>0.700)。全叶白质和深部T1值存在显著差异,分别。中晚期妊娠组之间的T1值存在显着差异。基底神经节,丘脑,内囊的后肢,temporal,和枕骨白质.T1值与孕周呈显著负相关(r=-0.80),基底神经节(r=-0.60),丘脑(r=-0.68),和内囊后肢(r=-0.77)。
可以使用MOLLI序列评估胎儿脑的T1值,并且可以反映髓鞘形成。
3技术效率:第2阶段。
Prenatal quantitative evaluation of myelin is important. However, few techniques are suitable for the quantitative evaluation of fetal myelination.
To optimize a modified Look-Locker inversion recovery (MOLLI) T1 mapping sequence for fetal brain development study.
Prospective observational preliminary cohort study.
A total of 71 women with normal fetuses divided into mid-pregnancy (gestational age 24-28 weeks, N = 25) and late pregnancy (gestational age > 28 weeks, N = 46) groups.
A 3 T/MOLLI sequence.
T1 values were measured in pedunculus cerebri, basal ganglia, thalamus, posterior limb of the internal capsule, temporal white matter, occipital white matter, frontal white matter, and parietal white matter by two radiologists (11 and 16 years of experience, respectively).
The Kruskal-Wallis test was used for reginal comparison. For each region of interest (ROI), differences in T1 values between the mid and late pregnancy groups were assessed by the Mann Whitney U test. Pearson correlation coefficients (r) were used to evaluate the correlations between T1 values and gestational age for each ROI. Intraobserver and interobserver agreement was determined by the intraclass correlation coefficient (ICC). A P value <0.05 was considered statistically significant.
Interobserver and intraobserver agreements of T1 were good for all ROIs (all ICCs > 0.700). There were significant differences in T1 values between lobal white matter and deep regions, respectively. Significant T1 values differences were found between middle and late pregnancy groups in pedunculus cerebri, basal ganglion, thalamus, posterior limb of the internal capsule, temporal, and occipital white matter. The T1 values showed significantly negative correlations with gestational weeks in pedunculus cerebri (r = -0.80), basal ganglion (r = -0.60), thalamus (r = -0.68), and posterior limb of the internal capsule (r = -0.77).
The T1 values of fetal brain may be assessed using the MOLLI sequence and may reflect the myelination.
3 TECHNICAL EFFICACY: Stage 2.