本实验旨在研究淋巴细胞亚群的变化,免疫球蛋白(Ig),和补充,探讨61例结节性红斑患者免疫指标与C反应蛋白和血沉的关系。为了这个目标,四年,回顾性研究包括61例结节性红斑患者,61名健康对照受试者来自门诊。T的亚群,B和自然杀伤淋巴细胞和IgA水平,IgG,IgM,补体C3,补体C4,C反应蛋白,并检测外周血的红细胞沉降率。淋巴细胞亚群之间进行了相关性分析,IgA水平,IgG,还有IgM,患者组的补体C3,补体C4和C反应蛋白水平以及红细胞沉降率。结果显示,CD4+细胞的百分比,CD4+/CD8+比值,患者的C反应蛋白水平和红细胞沉降率均高于对照组(P<0.05)。CD8+细胞百分比和血清补体C3水平低于对照组(P<0.05)。CD3+的百分比没有差异,B和自然杀伤细胞及血清IgA水平,IgG和IgM,患者和对照组之间的补体C4(P>0.05)。IgM水平与C反应蛋白呈正相关(P<0.05),与血沉无关(P>0.05)。淋巴细胞亚群之间无相关性,IgA水平,IgG,补体C3、补体C4和C反应蛋白水平与红细胞沉降率(P>0.05)。总之,结节性红斑患者的细胞免疫和体液免疫均失调。IgM水平与C反应蛋白呈正相关。
This experiment was carried out to investigate changes in lymphocyte subpopulation, immunoglobulins (Igs), and complements, and also to explore the relationship between these immune indices and C-reactive protein and erythrocyte sedimentation rate in 61 patients with erythema nodosum. For this aim, a 4-year, retrospective study contained 61 patients with erythema nodosum, and 61 healthy control subjects were included from the out-patient clinic. The subpopulation of the T, B and natural killer lymphocytes and levels of IgA, IgG, IgM, complement C3, complement C4, C-reactive protein, and erythrocyte sedimentation rate from peripheral blood of them were detected. A correlation analysis was done between lymphocyte subpopulation, levels of IgA, IgG, and IgM, complement C3, complement C4 and C-reactive protein level and erythrocyte sedimentation rate in the patient group. Results showed that the percentage of CD4+ cells, CD4+/CD8+ ratio, the level of C-reactive protein and the erythrocyte sedimentation rate in the patients were higher than in controls (P<0.05). While the percentage of CD8+ cells and the serum levels of complement C3 were lower than in controls (P<0.05). There were no differences in the percentages of CD3+, B and natural killer cells and the serum levels of IgA, IgG and IgM, and complement C4 between the patients and the controls (P>0.05). IgM level was positively correlated with C-reactive protein (P<0.05) but did not correlate with an erythrocyte sedimentation rate (P>0.05). There was no correlation between lymphocyte subpopulation, levels of IgA, IgG, complement C3, complement C4 and C-reactive protein level and erythrocyte sedimentation rate (P>0.05). In conclusion, there was dysregulation of both cellular immunity and humoral immunity in patients with erythema nodosum. IgM level has a positive correlation with C-reactive protein.