我们旨在比较三种跑步机跑步强度对健康个体运动诱发的痛觉减退（EIH）的影响。我们预计疼痛感知和调节的主要和次要变化可能在跑步强度之间有所不同。66名妇女被随机分配到三个跑步机跑步强度中的一个，持续35分钟：40％的保留心率（HRR），55%HRR，或70%的HRR。使用压力疼痛阈值（PPT）和耐受阈值（PPTol）评估EIH的效果。我们测量了条件性疼痛调节(CPM)。与基线相比，在跑步和5-10分钟随访期间，所有组的PPT和PPTol均显着增加。中等和低强度组的PPT和PPTol变化在跑步过程中和跑步后24h明显高于高强度组,而高强度组的CPM反应在24小时随访时显着降低。中等强度和低强度跑步可能会引起明显的原发性和继发性（持续24小时以上）EIH效应，并增加女性的CPM反应。然而,高强度跑步仅引起有限的镇痛作用和减少的CPM反应，这可能归因于内源性疼痛调节的激活。
We aimed to compare the effects of three intensities of treadmill running on exercise-induced hypoalgesia (EIH) in healthy individuals. We anticipated that the primary and secondary changes in pain perception and modulation may differ between running intensities. Sixty-six women were randomly assigned to one of three treadmill running intensities for 35 min: 40% reserved heart rate (HRR), 55% HRR, or 70% HRR. The effects of EIH were assessed using pressure pain thresholds (PPT) and tolerance thresholds (PPTol). We measured conditional pain modulation (CPM). Compared with baseline, PPT and PPTol significantly increased in all groups during running and at the 5-10-min follow-up. The PPT and PPTol changes in the moderate- and low-intensity groups were significantly higher than those in the high-intensity group during running and 24 h after running, while the CPM responses of the high-intensity group were significantly reduced at the 24-h follow-up. Moderate- and low-intensity running may elicit significant primary and secondary (persisting over 24 h) EIH effects and increase CPM responses in females. However, high-intensity running induced only limited analgesic effects and reduced CPM responses, which may be attributed to the activation of endogenous pain modulation.
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