UNASSIGNED:先前的研究表明,与控制良好的患者相比,控制不良的糖尿病患者的AP患病率更高,并且牙髓治疗可以改善糖尿病患者的代谢控制。该试验的目的是临床评估牙髓治疗对2型糖尿病(T2DM)和根尖周炎(AP)患者血糖控制的影响。
未经批准:对于本试验,AP+T2DM患者胰岛素注射(组1,G1,n=65),使用低血糖药物的AP+T2DM患者(组2,G2,n=82),纳入无DM的AP患者(组3,G3,n=86)。在完成人口统计学特征和临床检查后,对每位患者进行根管治疗(RCT).受试者随访2周,3和6个月。每次访问,采集血液样本并进行临床实验室研究.在6个月的随访中,根尖周指数(PAI)评分用于评估根尖周状态。
UNASSIGNED:将符合纳入标准的237名受试者分为三组,223名受试者(94.1%)完成了治疗和随访评估。治疗后,考虑到PAI,两组患者AP均有明显改善(P<0.05)。G3组患者随访时空腹血糖(FPG)浓度持续降低(P<0.05)。在大多数时间点观察到血红蛋白糖化(HbA1c)持续降低(P<0.05)。在整个审判过程中,短期炎症因子也有明显变化。
未经证实:牙髓治疗改善了AP愈合,各组T2DM和/或AP患者的血糖控制和全身炎症反应。然而,本试验未观察到短期炎症因子持续降低和HbA1c降低.
UNASSIGNED: Previous research has demonstrated that poor controlled diabetic showed higher prevalence of AP compared to well-controlled patients and endodontic treatment may improve metabolic control of patients with diabetes. The purpose of this trial was to clinically assess the effects of endodontic treatment on glycemic control in patients with type 2 diabetes mellitus (T2DM) and apical periodontitis (AP).
UNASSIGNED: For present trial, AP + T2DM with patients insulin injection (Group1, G1,n = 65), AP + T2DM patients with hypoglycaemic agents (Group2, G2, n = 82), and AP patients without DM (Group3, G3, n = 86) were enrolled. After demographic characteristics and clinical examination were achieved, root canal treatment (RCT) was performed for each patient. Subjects were followed up at 2-week, 3- and 6-month. At each visit, blood samples were taken and clinical laboratory studies were performed. At 6-month follow-up, Periapical Index (PAI) score was used to assess the periapical status.
UNASSIGNED: A total of 237 subjects who met the including criteria were allocated in three groups and 223 subjects (94.1%) completed the treatments and the follow-up assessments. After treatment, taking PAI into consideration, both groups showed significant improvement of AP in each group (P < 0.05). Patients in G3 had a continued significant lower concentration of fasting plasma glucose (FPG) levels at follow-up (P < 0.05). A continued reduction of hemoglobin glycation (HbA1c) was observed in most of time points (P < 0.05). Throughout the trial, there are also significant changes in inflammatory factors in short-term.
UNASSIGNED: Endodontic therapy improved AP healing, glycemic control and systemic inflammation in patients with T2DM and/or AP in each group. However, a continued reduction in inflammatory factors and decreasing of HbA1c in short-term could not be observed in this trial.