■评估视网膜手术对眼表和角膜基底下神经丛(SNP)的影响。
■前瞻性研究了98例接受23号平面玻璃体切除术治疗各种玻璃体视网膜疾病的患者。我们收集了详细的手术和围手术期数据,术前和术后间隔测量干眼综合征(DED)严重程度和眼表疾病指数(OSDI)评分。体内共聚焦显微镜(IVCM)定量SNP和树突状细胞(DC)密度。
■分析了53例患者。手术后,OSDI评分从基线的5.5±3.5上升到一个月的12.24±6.5,一年后减少到7.8±4.0。DED严重程度从最初的0.6±0.6增加到三个月的1.6±0.6,术后1年恢复至接近基线(0.9±0.6).术后第3个月(58.85±75.6个细胞/mm²)和第9个月(59.95±86个细胞/mm²),DC密度显着增加,尤其是在接受联合超声乳化手术的患者中,玻璃体切除术,还有C3F8气体填塞.SNP参数,特别是神经纤维的密度和长度,手术后一个月显示显着下降,一年内没有恢复到基线水平。纤维密度从术前的19.06±8.3纤维/mm²下降到一个月的4.68±4.8纤维/mm²,12个月时部分恢复到10.64±8.2纤维/mm²。纤维长度在一个月时从13.31±3.2mm/mm²减少到6.86±3.4mm/mm²,后来在十二个月时提高到9.81±4.5mm/mm²,特别是在患者与硅油(SiO2)填塞。
■视网膜手术,尤其是与超声乳化和C3F8或SiO2填塞联合使用时,显著影响眼表完整性和SNP密度,这些变化持续了一年。扩大研究与更多的患者和更长的随访,使用更精细的25号和27号玻璃体切割工具,建议确认和扩展这些发现。
UNASSIGNED: To evaluate the effects of retinal surgery on the ocular surface and corneal subbasal nerve plexus (SNP).
UNASSIGNED: Ninety-eight patients undergoing 23-gauge pars plana vitrectomy for various vitreoretinal disorders were prospectively studied. We collected detailed operative and perioperative data, measuring dry eye syndrome (DED) severity and Ocular Surface Disease Index (OSDI) scores before surgery and at postoperative intervals. In vivo confocal microscopy (IVCM) quantified SNP and dendritic cell (DC) densities.
UNASSIGNED: Fifty-three patients were analyzed. Post-surgery, OSDI scores rose from a baseline of 5.5 ± 3.5 to 12.24 ± 6.5 at one month, later reducing to 7.8 ± 4.0 after a year. DED severity increased from 0.6 ± 0.6 initially to 1.6 ± 0.6 at three months, returning to near baseline (0.9 ± 0.6) one year after surgery. DC densities increased notably by the third (58.85 ± 75.6 cells/mm²) and ninth (59.95 ± 86 cells/mm²) postoperative months, especially in patients undergoing combined phacoemulsification, vitrectomy, and C3F8 gas tamponade. SNP parameters, particularly nerve fiber density and length, showed significant declines one month post-surgery, not recovering to baseline levels within a year. Fiber density dropped from 19.06 ± 8.3 fibers/mm² preoperatively to 4.68 ± 4.8 fibers/mm² at one month, partially recovering to 10.64 ± 8.2 fibers/mm² at twelve months. Fiber length decreased from 13.31 ± 3.2 mm/mm² to 6.86 ± 3.4 mm/mm² at one month, later improving to 9.81 ± 4.5 mm/mm² at twelve months, notably in patients with silicone oil (SiO2) tamponade.
UNASSIGNED: Retinal surgery, especially when combined with phacoemulsification and C3F8 or SiO2 tamponade, significantly affects ocular surface integrity and SNP density, with these changes lasting up to a year. Expanded studies with more patients and longer follow-up, using finer 25- and 27-gauge vitrectomy tools, are recommended to confirm and extend these findings.