背景:为了描述儿童中枢神经系统(CNS)肿瘤的流行病学特征,北京天坛医院神经外科。
方法:2015年1月至2019年12月,根据2016年世界卫生组织(WHO)肿瘤分类,对3180名儿童进行组织病理学诊断为CNS肿瘤。患者年龄为0至15岁。我们分析了与年龄相关的性别偏好,肿瘤位置,以及肿瘤的组织学分级.此外,将五种最常见的颅内肿瘤的流行病学特征与以前的研究进行了比较.
结果:在这项研究中,颅内和脊柱肿瘤占所有肿瘤的96.4%(3066)和3.6%(114),以幕上肿瘤为主(57.9%)。在所有儿科患者中,低度肿瘤占67.1%(2135)。男女比例为1.47:1,患者平均年龄为7.59岁。最常见的五种颅内肿瘤是颅咽管瘤(15.4%),髓母细胞瘤(14.3%),毛细胞星形细胞瘤(11.8%),弥漫性星形细胞瘤(9.8%),和间变性室管膜瘤(4.8%)。
结论:由于缺乏关于儿童脑肿瘤的国家数据,我们基于中国最大的儿科神经外科中心,使用了具有全国代表性的大型人群样本.我们分析了过去5年的数据,在一定程度上反映了中国儿童中枢神经系统肿瘤的发病率,为后续临床研究奠定数据基础。
BACKGROUND: To describe the epidemiological characteristics of central nervous system (CNS) tumors in children, based on the neurosurgery department of Beijing Tiantan Hospital.
METHODS: From January 2015 to December 2019, 3180 children were histopathologically diagnosed with CNS tumors based on the 2016 World Health Organization (WHO) classification of tumors. Patients were 0 to 15 years old. We analyzed age-related gender preferences, tumor locations, and the histological grades of the tumors. In addition, the epidemiological characteristics of the five most common intracranial tumors were compared to the previous studies.
RESULTS: In this study, intracranial and spinal tumors account for 96.4% (3066) and 3.6% (114) of all tumors, with a preponderance of supratentorial tumors (57.9%). Among all pediatric patients, low-grade tumors comprise 67.1% (2 135). The integral gender ratio of males to females is 1.47: 1 and the average age of patients is 7.59 years old. The five most common intracranial tumors are craniopharyngioma (15.4%), medulloblastoma (14.3%), pilocytic astrocytoma (11.8%), diffuse astrocytoma (9.8%), and anaplastic ependymoma (4.8%).
CONCLUSIONS: Due to the lack of national data on childhood brain tumors, we used a large nationally representative population sample based on the largest pediatric neurosurgery center in
China. We analyzed the data of the past 5 years, reflecting the incidence of CNS tumors in Chinese children to a certain extent, and laying a data foundation for subsequent clinical studies.