未经批准:贫血仍然是一个未解决的全球健康问题,不良的出生体重结局对晚年的健康有持久的影响。然而,孕妇血红蛋白与出生体重结局的非线性联系和断点仍需进一步阐明.我们的目的是揭示妊娠晚期母体血红蛋白与出生体重之间的非线性联系,低出生体重(LBW),巨大儿,小于胎龄(SGA),足月新生儿的胎龄(LGA)大,并阐明了连接的断点。
未经评估:总共11,411个单身人士,全学期,还有活的新生儿,其母亲在分娩前进行了血红蛋白浓度检查,包括在这项研究中。使用广义加性模型来识别和可视化母体血红蛋白与出生体重结果之间的非线性联系。采用分段线性回归模型来估计连接的断点,并详细报告非线性连接。
UNASSIGNED:母体血红蛋白浓度和出生体重与巨大儿风险之间存在倒置的“U”形暴露-反应联系。随着母体血红蛋白浓度的增加,LBW的风险呈增加趋势,LGA呈降低趋势。母亲血红蛋白与出生体重的断点分别为100和138g/L,SGA分别为97和138g/L。LBW的母体血红蛋白的断点为119g/L,105克/升的巨大儿,和106g/L的LGA。当母体血红蛋白浓度范围为100至138g/L时,母体血红蛋白浓度每增加1g/L,出生体重显著下降2.58g(95%CI:-3.33,-1.83)。当母体血红蛋白浓度范围为97至138g/L时,母体血红蛋白浓度每增加1g/L,SGA的风险显著增加2%(95%CI:1%,3%)。当母体血红蛋白浓度等于或低于119g/L时,母体血红蛋白浓度每增加1g/L,LBW的风险显着增加了3%(95%CI:0%,5%)。当母体血红蛋白浓度高于断点时,巨大儿(OR=0.99,95%CI:0.98,0.99)和LGA(OR=0.99,95%CI:0.98,1.00)的风险随着母体血红蛋白浓度的增加而下降。
未经评估:母体血红蛋白和出生体重之间存在非线性联系,并且在连接中存在断点。应针对孕妇采取成本有效的干预措施预防孕妇血红蛋白浓度异常,以减少不良出生体重结局的发生率。
UNASSIGNED: Anemia is still an unfinished global health problem, and adverse birth weight outcomes have everlasting influences on the health of later life. However, the non-linear connections and
breakpoints of maternal hemoglobin with birth weight outcomes are still needed to be further elucidated. We aimed to reveal the non-linear connections between maternal hemoglobin during the third trimester of pregnancy and birth weight, low birth weight (LBW), macrosomia, small for gestational age (SGA), and large for gestational age (LGA) in full-term newborns and elucidate the breakpoints of the connections.
UNASSIGNED: A total of 11,411 singletons, full-term, and live newborns, whose mothers conducted the examination of hemoglobin concentration before delivery, were included in this study. A generalized additive model was used to identify and visualize the non-linear connections between maternal hemoglobin and birth weight outcomes. Piecewise linear regression model was adopted to estimate the
breakpoints of the connections and report the non-linear connections in detail.
UNASSIGNED: There were inverted \"U\"-shaped exposure-response connections between maternal hemoglobin concentration and birth weight and the risk of macrosomia. There was an increasing trend of the risk of LBW and a decreased trend of LGA with the increase in maternal hemoglobin concentration. The
breakpoints of maternal hemoglobin for birth weight were 100 and 138 g/L, and those for SGA were 97 and 138 g/L. The
breakpoints of maternal hemoglobin were 119 g/L for LBW, 105 g/L for macrosomia, and 106 g/L for LGA. When maternal hemoglobin concentration ranged from 100 to 138 g/L, maternal hemoglobin concentration increased per 1 g/L, and birth weight significantly decreased by 2.58 g (95% CI: -3.33, -1.83). When maternal hemoglobin concentration ranged from 97 to 138 g/L, maternal hemoglobin concentration increased per 1 g/L, and the risk of SGA significantly increased by 2% (95% CI: 1%, 3%). When maternal hemoglobin concentration was equal to or lower than 119 g/L, maternal hemoglobin concentration increased per 1 g/L, and the risk of LBW significantly increased by 3% (95% CI: 0%, 5%). When maternal hemoglobin concentration was higher than the
breakpoints, the risks of macrosomia (OR = 0.99, 95% CI: 0.98, 0.99) and LGA (OR = 0.99, 95% CI: 0.98, 1.00) declined as the increase of maternal hemoglobin concentration.
UNASSIGNED: There were non-linear connections between maternal hemoglobin and birth weight outcomes, and there are breakpoints in the connections. Cost-effective interventions targeting pregnant women in the prevention of abnormal maternal hemoglobin concentration should be taken to reduce the incidence of adverse birth weight outcomes.