■本研究旨在确定不同方法在常染色体显性遗传多囊肾病(ADPKD)的亚太患者中预测快速进展者(RP)及其临床特征的实用性。
■这是一项针对亚太地区ADPKD患者的多国回顾性观察队列研究。来自澳大利亚的五家医院,中国,韩国,台湾,土耳其参加了这项研究。RP由欧洲肾脏协会-欧洲透析和移植协会(ERA-EDTA)指南定义,并与缓慢进展者(SP)进行比较。
■在768名患者中,426例患者为RP。三百六位患者仅满足1项标准,而120位患者满足RP的多项标准。历史估计的肾小球滤过率(eGFR)下降符合210例患者的RP标准。五名患者符合身高调整后的总肾脏体积(TKV)历史增加的标准。210例患者满足基于肾体积的标准。在后续期间,囊肿感染,囊肿出血,和蛋白尿更频繁发生在RP中;13.9%和2.1%的RP和SP,分别,进展为终末期肾病(ESKD)。基于历史eGFR下降的RP标准与2年随访期间eGFR变化的相关性最强。
■在随访期间,在现实临床实践中,应使用各种评估策略来识别亚太ADPKD患者的RP,囊肿感染,囊肿出血,蛋白尿的发生频率更高;与SPs相比,更多的患者在RP中进展为ESKD。
UNASSIGNED: This study aimed to determine the utility of different methods to predict rapid progressors (RPs) and their clinical characteristics in Asia-Pacific patients with autosomal dominant polycystic kidney disease (ADPKD).
UNASSIGNED: This was a multinational retrospective observational cohort study of patients with ADPKD in the Asia-Pacific region. Five hospitals from Australia,
China, South Korea, Taiwan, and Turkey participated in this study. RP was defined by European Renal Association-European Dialysis and Transplantation Association (ERA-EDTA) guidelines and compared to slow progressors (SPs).
UNASSIGNED: Among 768 patients, 426 patients were RPs. Three hundred six patients met only 1 criterion and 120 patients satisfied multiple criteria for RP. Historical estimated glomerular filtration rate (eGFR) decline fulfilled the criteria for RP in 210 patients. Five patients met the criteria for a historical increase in height-adjusted total kidney volume (TKV). The 210 patients satisfied the criteria for based on kidney volume. During the follow-up period, cyst infections, cyst hemorrhage, and proteinuria occurred more frequently in RP; and 13.9% and 2.1% of RPs and SPs, respectively, progressed to end-stage kidney disease (ESKD). RP criteria based on historical eGFR decline had the strongest correlation with eGFR change over a 2-year follow-up.
UNASSIGNED: Various assessment strategies should be used for identifying RPs among Asian-Pacific patients with ADPKD in real-world clinical practice during the follow-up period, cyst infections, cyst hemorrhage, and proteinuria occurred more frequently; and more patients progressed to ESKD in RPs compared with SPs.