背景:先前的证据表明血脂异常与骨骼健康可能存在联系。然而,残余胆固醇(RC)与骨矿物质密度(BMD)的相关性尚未得到很好的研究。这项研究调查了普通美国人的RC与总脊柱BMD的关系。
方法:本研究从2013-2018年国家健康与营养调查(NHANES)中探讨了年龄≥20岁受试者的RC与总脊柱BMD的关系。在调整协变量后,进行了多元线性回归和分层分析,以确定成年美国人血清RC与总脊柱BMD的相关性。应用限制性三次样条(RCS)检查血清RC与总脊柱BMD的非线性关联。
结果:本研究纳入3815名年龄≥20岁的个体,1905年(49.93%)是男性,1910年(50.07%)是女性。在调整所有协变量后,结果显示血清RC与脊柱总骨密度呈负相关(β=-0.024,95%CI:-0.039,-0.010)。年龄的相互作用测试,性别,种族,和BMI对该关联没有统计学意义的影响。RCS还表明血清RC与总脊柱BMD呈负线性相关(非线性P=0.068,总体P<0.001)。此外,RC对脊柱总骨密度的影响强于总胆固醇(TC),低密度脂蛋白胆固醇(LDL-C),和高密度脂蛋白胆固醇(HDL-C)。
结论:这项研究发现,在美国成年人中,血清RC与脊柱总骨密度呈负相关。这些发现强调了RC在美国成年人骨骼健康中的重要作用。
BACKGROUND: Previous evidence showed a possible link of dyslipidemia with bone health. Nevertheless, the correlation of remnant cholesterol (RC) with bone mineral density (BMD) has yet to be well investigated. This study investigated the association of RC with total spine BMD in general
Americans.
METHODS: This study explored the relationship of RC with total spine BMD in subjects aged ≥ 20 years from the National Health and Nutrition Examination Survey (NHANES) 2013-2018. After adjusting for covariates, multivariate linear regression and stratified analyses were conducted to determine the correlation of serum RC with total spine BMD in adult
Americans. Restricted cubic spline (RCS) was applied to examine the nonlinear association of serum RC with total spine BMD.
RESULTS: This study included 3815 individuals ≥ 20 years old, 1905 (49.93%) of whom were men and 1910 (50.07%) of whom were women. After adjusting for all covariates, the results showed a negative relationship of serum RC with total spine BMD (β= -0.024, 95% CI: -0.039, -0.010). The interaction tests of age, sex, race, and BMI showed no statistically significant effects on the association. The RCS also indicated a negative linear correlation of serum RC with total spine BMD (nonlinear P = 0.068, overall P < 0.001). Moreover, RC had a stronger effect on total spine BMD than total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C).
CONCLUSIONS: This study found that serum RC was negatively related to total spine BMD in U.S. adults. These findings emphasized the important role of RC in bone health in American adults.