目的：本研究旨在从先前诊断的牙源性鬼细胞瘤（DGCT）病例中鉴定腺样体成釉细胞瘤（AdAM）。并深入了解AdAM和DGCT之间可能的关系。
方法：重新检查2006年至2022年诊断的DGCT病例，重点关注AdAM样特征。
结果：共纳入9例患者。7名患者为男性，2名为女性。平均年龄为38.0±16.0岁。五个肿瘤发生在上颌骨，四个在下颌骨，对两个颌骨的后部区域有明显的偏爱。微观上,在所有情况下都存在类齿物质沉积。两种情况下均不存在鬼细胞。在3例中观察到罕见的鬼细胞（<1％），其余4例存在较高比例的鬼影细胞(5%-20%)。所有病例均表现出明显的AdAM样特征,包括管道状结构，螺纹/modules，和章状建筑。根据2022年WHO分类提出的诊断标准，5例无或有罕见鬼细胞的病例被重新分类为AdAM。其他四例包括较高比例的鬼细胞，由DGCT和AdAM组织病理学模式的混合物组成。
结论：我们的结果证实，过去在我们机构的DGCT诊断中，AdAM样特征在很大程度上被忽视。虽然一个子集现在可以更准确地分类为AdAM，一些肿瘤在AdAM和DGCT之间表现出重叠的形态学特征，这表明两者可能代表同一实体的光谱。
OBJECTIVE: The present study aims to identify adenoid ameloblastoma (AdAM) from previously diagnosed cases of dentinogenic ghost cell tumor (DGCT), and gain insight to the possible relationship between AdAM and DGCT.
METHODS: DGCT cases diagnosed between 2006 and 2022 were re-examined with focus on the AdAM-like features.
RESULTS: A total of nine patients were included. Seven patients were males and two were females. The mean age was 38.0 ± 16.0 years. Five tumors occurred in the maxilla and four in the mandible, with a remarkable predilection for the posterior regions of both jaws. Microscopically, dentinoid material deposition was present in all cases. The ghost cells were absent in two cases. Rare ghost cells (<1%) were observed in three cases, and a higher proportion of ghost cells (5%-20%) were present in the remaining four cases. All cases showed prominent AdAM-like features, including duct-like structures, whorls/morules, and cribriform architecture. According to the diagnostic criteria proposed by the 2022 WHO classification, five cases without or with rare ghost cells were reclassified as AdAM. The other four cases including a higher proportion of ghost cells consisted of a mixture of DGCT and AdAM histopathologic patterns.
CONCLUSIONS: Our results confirmed that the AdAM-like features had been largely overlooked in the diagnosis of DGCT at our institution in the past. Whilst a subset can now be more accurately classified as AdAM, some tumors showed overlapping morphological features between AdAM and DGCT, suggesting that the two may represent a spectrum of the same entity.
