背景:在常规临床实践中,口腔放线菌败血症和隐球菌性脑炎的联合感染很少见。因此,我们提出了这一病例报告和文献综述,以提供线索,以改善此类患者的诊断和治疗过程。
方法:患者的主要临床表现为高热和颅内高压。然后,我们完成了常规的脑脊液检查,生化检测,细胞学检查,细菌培养,和印度墨水染色。首先,血培养提示放线菌感染,考虑放线菌败血症和颅内放线菌感染的可能性。因此,患者接受青霉素治疗。虽然发烧略有缓解,颅内高压的症状没有缓解。7天后,脑磁共振成像特点及病原宏基因组学测序结果和隐球菌荚膜多糖抗原提示隐球菌感染。基于以上结果,该患者被诊断为隐球菌性脑膜脑炎和放线菌败血症的联合感染。青霉素抗感染治疗,两性霉素,并提供了氟康唑,改善临床表现和客观指标。
结论:本病例报告首次报道牙周放线菌败血症和隐球菌性脑炎合并感染,并将抗生素与青霉素联合使用,两性霉素,和氟康唑是有效的。
BACKGROUND: The combined infection of actinomyces odontolyticus sepsis and cryptococcal encephalitis is rare in routine clinical practice. Thus, we presented this case report and literature review to provide clues to improve such patients\' diagnoses and treatment processes.
METHODS: The main clinical manifestations of the patient were high fever and intracranial hypertension. Then, we completed the routine cerebrospinal fluid examination, biochemical detection, cytological examination, bacterial culture, and India ink staining. Firstly, the blood culture suggested actinomyces odontolyticus infection, considering the possibility of actinomyces odontolyticus sepsis and intracranial actinomyces odontolyticus infection. Accordingly, the patient was administered penicillin for treatment. Although the fever was slightly relieved, the symptoms of intracranial hypertension did not relieve. After 7 days, the characteristics of brain magnetic resonance imaging and the results of pathogenic metagenomics sequencing and cryptococcal capsular polysaccharide antigen suggested that cryptococcal infection. Based on the above results, the patient was diagnosed with a combined infection of cryptococcal meningoencephalitis and actinomyces odontolyticus sepsis. Anti-infection therapy with \'penicillin, amphotericin, and fluconazole\' was provided, improving the clinical manifestations and objective indexes.
CONCLUSIONS: The combined infection of Actinomyces odontolyticus sepsis and cryptococcal encephalitis is first reported in this case report, and combined antibiotics with \'penicillin, amphotericin, and fluconazole\' are effective.