■探讨高血压患者Tpeak-Tend间期(Tpe)和Tpe/QT比值与室性早搏(VPBs)和左心室重构的关系。
■共纳入52例轻度至中度原发性高血压患者，接受超声心动图和24小时动态心电图监测。使用Devereux公式通过左心室质量指数（LVMI）评估心室重构，并通过E和A波速度以及E/A比评估舒张功能。在心前导联中测量Tpe。T波的末端是通过与T波的最陡下降斜率相切的方法设置的。
■导联V2（r=0.33，P=0.01；r=0.27，P=0.04）和V3（r=0.40，P=0.002；r=0.40，P=0.003）中的Tpe和Tpe/QT与LVMI显着相关。E/A比值与QT呈显著负相关(r=-0.33,P=0.01),V3中的Tpe（r=-0.39，P=0.003）和V3中的Tpe/QT（r=-0.31，P=0.02）。V3、V5中的Tpe，截止值为60ms的平均Tpe和最大Tpe，59ms,62ms和71ms，分别,与室性早搏的发生有关。
■复极参数Tpe间期和Tpe/QT比值与LVMI和左心室舒张功能指标相关，并显示出比传统参数如QT间期和QT离散度更好的预测值。V3引线是测量Tpe和Tpe/QT的最佳引线。因此,这些ECG指标可以在临床实践中用于监测LV重塑并预测VPB的发生。
UNASSIGNED: To examine the relationship between Tpeak- Tend interval (Tpe) and Tpe/QT ratio with occurrence of ventricular premature beats (VPBs) and left ventricular remodeling in hypertension.
UNASSIGNED: A total of 52 patients with mild to moderate essential hypertension were included, undergoing echocardiography and 24-hours Holter monitoring. Ventricular remodeling was assessed by left ventricular mass index (LVMI) using the Devereux formula and diastolic function by transmitral E and A wave velocities and E/A ratio. Tpe was measured in the precordial leads. The end of the T wave was set by the method of the tangent to the steepest descending slope of the T wave.
UNASSIGNED: Tpe and Tpe/QT in leads V2 (r = 0.33, P = 0.01; r = 0.27, P = 0.04 respectively) and V3 (r = 0.40, P = 0.002; r = 0.40, P = 0.003, respectively) correlated significantly with LVMI. A significant inverse relationship was observed between E/A ratio and QT (r = -0.33, P = 0.01), Tpe in V3 (r = -0.39, P = 0.003) and Tpe/QT in V3 (r = -0.31, P = 0.02). Tpe in V3, V5, mean Tpe and maximum Tpe with cut-off values of 60 ms, 59 ms, 62 ms and 71 ms, respectively, associated with the occurrence of ventricular premature beats.
UNASSIGNED: The repolarization parameters Tpe interval and Tpe/QT ratio correlate with LVMI and indices of left ventricular diastolic function and show better predictive values than traditional parameters such as QT interval and QT dispersion. Lead V3 is the best lead for measuring Tpe and Tpe/QT. These ECG indices can therefore be used in clinical practice to monitor LV remodeling and predict occurrence of VPBs.
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