■系统性红斑狼疮(SLE)是一种慢性自身免疫性疾病,会影响多个系统。SLE患者易发生多种恶性肿瘤,尤其是女性生殖道的肿瘤。同步肿瘤,被认为涉及多个网站,在女性生殖道中很少见。几乎没有任何与生殖道肿瘤同步的SLE的报道。
■我们报告了两名SLE女性中两到三个生殖道肿瘤的发生情况。一名52岁的妇女被诊断出患有外阴癌和宫颈癌。另一个女人,67岁,被诊断为并发外阴癌,阴道癌,和宫颈癌,还出现了疑似肺癌。
■SLE患者生殖道同步肿瘤的存在并不常见,很容易被忽视。重要的是要强调患有多原发恶性肿瘤的SLE患者在诊断时表现出明显的晚期表现。无病生存不足,总体生存率低,快速进展率,和死亡率。因此,必须提高对SLE患者并发生殖道肿瘤的认识。对于诊断为SLE的个体,应定期进行全面的癌症筛查和管理。
UNASSIGNED: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that affects multiple systems. Patients with SLE are prone to a variety of malignancies, especially neoplasms of the female reproductive tract. Synchronous tumors, considered to involve multiple sites, are rare in the female reproductive tract. There are hardly any reports of SLE with synchronous reproductive tract tumors.
UNASSIGNED: We report the occurrence of two to three reproductive tract tumors in two women with SLE. A 52-year-old woman was diagnosed with vulvar cancer and cervical cancer. Another woman, aged 67, was diagnosed with concurrent vulvar cancer, vaginal cancer, and cervical cancer and also presented with a suspected lung cancer.
UNASSIGNED: The presence of synchronous tumors of the reproductive tract in patients with SLE is uncommon and can be easily disregarded. It is crucial to highlight that SLE patients with multiple primary malignancies exhibit notable late-stage presentation at the time of diagnosis, inadequate disease-free survival, poor overall survival, rapid progression rates, and mortality. Consequently, greater awareness must be raised regarding synchronous reproductive tract tumors in patients with SLE. Regular comprehensive cancer screening and management should be implemented for individuals diagnosed with SLE.