评估局部应用万古霉素(TV)对减少心脏手术(CS)后胸骨伤口感染(SWIs)的影响,我们负责荟萃分析。两万三千七百四十五名参与者在调查开始时患有CS，根据对截至2022年11月的文献的全面评估；其中8730人使用电视，而15015是对照。为了评估电视应用在降低CS后SWI方面的有效性，采用固定或随机效应模型,采用二分法计算比值比(OR)和95%置信区间(CIs).电视在CS后的SWI明显较低(或，0.34；95%CI，0.20-0.57；P<.001），和深SWIs后CS(或，0.26；95％CI，0.11-0.65；P=.004）与对照组相比，如图2和3所示。然而，在CS后的浅表SWIs中，电视和对照之间没有发现显着差异(OR，0.30；95%CI，0.07-1.30；P=.011）。电视的SWI明显较低，和深SWIs后CS，与对照组相比，CS后的浅表SWIs没有发现显着差异。在这项针对表面SWIs的荟萃分析中，纳入研究的数量很少，因此在分析结果时需要采取预防措施。
To assess the impact of topical vancomycin (TV) application in decreasing sternal wound infections (SWIs) post cardiac surgery (CS), we lead a meta-analysis. Twenty-three thousand seven hundred and forty five participants had CS at the outset of the investigations, according to a thorough evaluation of the literature done up to November 2022; 8730 of them used TV, while 15 015 were controls. To assess the effectiveness of TV application in lowering SWIs following CS, odds ratios (OR) with 95% confidence intervals (CIs) were computed with dichotomous technique with a fixed- or random-effect model. The TV had significantly lower SWIs post CS (OR, 0.34; 95% CI, 0.20-0.57; P < .001), and deep SWIs post CS (OR, 0.26; 95% CI, 0.11-0.65; P = .004) compared with control as shown in Figures 2 and 3. Yet, there was no significant difference found amongst TV and control in superficial SWIs post CS (OR, 0.30; 95% CI, 0.07-1.30; P = .011). The TV had significantly lower SWIs, and deep SWIs post CS, and no significant difference was found in superficial SWIs post CS compared with control. The low number of included studies in this meta-analysis for superficial SWIs calls for precaution when analysing the outcomes.
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