■耐多药结核病(MDR-TB)仍然是一个公共卫生问题。2019年,全球共有46.5万人发展为利福平耐药结核病(RR-TB)。其中78%患有耐多药结核病。埃塞俄比亚南部耐多药结核病的决定因素缺乏证据。因此,本研究旨在评估埃塞俄比亚南部耐多药结核病的决定因素.
■在埃塞俄比亚南部进行了一项基于医院的病例对照研究。这些病例都是在结核病诊所就诊的耐多药结核病患者,对照组为所有宣布治愈或治疗完成的患者.通过连续抽样选择病例,并将简单的随机抽样技术用于对照。进行多变量逻辑回归分析以确定MDR-TB的决定因素。计算了具有95%置信区间(CI)的调整后优势比(AORs),并且在P值小于5%时宣布有统计学意义。
■共有191名参与者,67例,包括124个对照。结核病患者面临社会耻辱(AOR=8.9,95%CI:2.3-34.6),住在一个有一个房间的家庭(AOR=12.3,95%CI:2.3-63.5),和两个房间(AOR=9.7,95%CI:1.7-54.8),有结核病治疗史(AOR=11.8,95%CI:2.9-47),基线体重指数(BMI)小于18.5Kg/m2(AOR=4.5,95%CI:1.2-16.8),和肺结核(AOR=5.1,95%CI:1.33-19.8)是MDR-TB的决定因素。
■在这项研究中,结核病患者面临社会耻辱,住在一室和两室的房子里,有结核病治疗史,具有低基线BMI和肺部类型的TB的MDR-TB的几率较高.因此,结核病控制计划中的卫生工作者应将精神卫生服务纳入结核病护理方案,应优先考虑将营养不良筛查作为一线诊断,营养补充剂,和关于适当住房的健康教育。
UNASSIGNED: Multidrug-resistant tuberculosis (MDR-TB) continues to be a public health problem. Globally in 2019, a total of 465,000 people developed rifampicin-resistant TB (RR-TB), of which 78% had MDR-TB. There is a paucity of evidence on the determinants of MDR-TB in southern Ethiopia. Hence, this study aimed to assess the determinants of MDR-TB in southern Ethiopia.
UNASSIGNED: A hospital-based case-control study was conducted in southern Ethiopia. The cases were all MDR-TB patients attending TB clinics, and controls were all patients who were declared as cured or treatment completed. The cases were selected by consecutive sampling, and a simple random sampling technique was used for controls. Multivariable logistic regression analysis was done to identify determinants of MDR-TB. Adjusted odds ratios (AORs) with 95% confidence intervals (CIs) were computed, and statistical significance was declared at a P-value less than 5%.
UNASSIGNED: A total of 191 participants, 67 cases, and 124 controls were included. TB patients facing social stigma (AOR = 8.9, 95% CI: 2.3-34.6), living in a household with one room (AOR = 12.3, 95% CI: 2.3-63.5), and two rooms (AOR = 9.7, 95% CI: 1.7-54.8), having the previous history of TB treatment (AOR = 11.8, 95% CI: 2.9-47), having baseline body mass index (BMI) less than 18.5Kg/m2(AOR = 4.5, 95% CI: 1.2-16.8), and having pulmonary TB (AOR = 5.1, 95% CI: 1.33-19.8) were determinants of MDR-TB.
UNASSIGNED: In this study, TB patients facing social stigma, living in one- and two-roomed houses, having a previous history of TB treatment, having low baseline BMI and pulmonary type of TB had higher odds of MDR-TB. Therefore, health workers in TB control programs should include mental health services in the TB care protocol, and priority should be given to malnutrition screening as a first-line diagnosis, nutritional supplements, and health education about proper housing.