■本系统综述的目的是评估唇裂和/或腭裂(CL/P)患者骨骼成熟的证据,并调查这些患者骨骼成熟是否延迟。
■系统评价。
■在4个数据库(MEDLINE,Embase,科克伦图书馆,和WebofScience)。将CL/P患者的骨骼成熟度与无CL/P儿童的骨骼成熟度进行比较的队列研究符合纳入条件。使用纽卡斯尔-渥太华量表评估纳入队列研究的质量。
■任何性别和种族的CL/P患者和无CL/P的儿童纳入本系统评价。
■有CL/P的患者和无CL/P的患者之间骨骼成熟的差异
■本系统综述包括13项回顾性队列研究。10项研究被认为是高质量的,3项被认为是一般质量的。纳入的比较CL/P患者和无CL/P儿童骨骼成熟的研究结果是异质的。
■骨骼成熟评估方法的异质性,实际年龄,性别,裂隙类型,和种族可能会影响临床研究对CL/P患者骨骼成熟的最终结果。总的来说,与正常儿童相比,确定CL/P患者的骨骼成熟水平是否延迟的证据有限.需要进一步的研究来确定CL/P患者的骨骼成熟模式。
UNASSIGNED: The objective of this systematic review was to evaluate the evidence regarding skeletal maturation in patients with cleft lip and/or palate (CL/P) and to investigate whether the skeletal maturation is delayed in these patients.
UNASSIGNED: Systematic review.
UNASSIGNED: Electronic and manual searches of scientific literature were conducted in 4 databases (MEDLINE, Embase, Cochrane Library, and Web of Science). Cohort studies that compared the skeletal maturation of patients with CL/P with that of children without CL/P were eligible for inclusion. The quality of included cohort studies was assessed using the Newcastle-Ottawa Scale.
UNASSIGNED: Patients of any sex and ethnicity with CL/P and children without CL/P were included in this systematic review.
UNASSIGNED: Difference in skeletal maturation between patients with CL/P and patients without CL/P.
UNASSIGNED: Thirteen retrospective cohort studies were included in this systematic review. Ten studies were considered of high quality and 3 were considered of general quality. The results of the included studies comparing skeletal maturation of patients with CL/P and children without CL/P were heterogeneous.
UNASSIGNED: Heterogeneity of skeletal maturation assessment methods, chronological age, sex, cleft type, and race may influence the final results of clinical studies on skeletal maturation in patients with CL/P. Overall, there is limited evidence to determine whether the skeletal maturation level of patients with CL/P is delayed compared to that of normal children. Further studies are needed to determine the skeletal maturation patterns in patients with CL/P.