背景:一些观察性研究探讨了1型糖尿病女性中女性性功能障碍(FSD)的患病率和预测因素。然而,没有对汇总数据的系统评价和荟萃分析提供了女性1型糖尿病患者FSD患病率的可靠估计.
目的:调查FSD的全球患病率,分析FSD风险与1型糖尿病之间的关系,并评估女性1型糖尿病患者FSD的预测因子。
方法:本系统综述的研究检索是通过万方数据库进行的,中国国家知识基础设施,PubMed,和Embase从开始日期到2023年2月28日。用Q和I2检验分析研究之间的异质性。通过亚组分析和荟萃回归检测异质性的来源。
结果:结果包括1型糖尿病女性FSD的合并患病率,FSD风险与1型糖尿病之间的关系,以及女性1型糖尿病患者FSD的预测因素。
结果:女性1型糖尿病合并FSD的患病率为38.5%(95%CI,32.1%-45.0%)。1型糖尿病患者的FSD风险高于健康对照组(比值比[OR],3.77;95%CI,2.24-6.35)。女性1型糖尿病患者FSD的显著预测因素是抑郁状态(OR,2.77;95%CI,1.29-5.93)和更长的糖尿病病程(OR,1.19;95%CI,1.06-1.34)。
结论:女性1型糖尿病患者的FSD患病率明显增加,这表明临床医生应该关注女性1型糖尿病患者的FSD。
■本研究的优势在于,它是第一个系统评价和荟萃分析,以调查1型糖尿病女性中FSD的全球患病率和预测因素。局限性在于,结果在汇集文章后显示出明显的异质性。
结论:本系统综述和荟萃分析显示,女性1型糖尿病患者的FSD总体患病率为38.5%,证明女性FSD风险与1型糖尿病之间存在显着关联。此外,我们发现,女性1型糖尿病患者FSD的重要预测因素是抑郁和糖尿病病程较长.
Several observational studies have explored the prevalence and predictors of female sexual dysfunction (FSD) among females with type 1 diabetes. However, no systematic review and meta-analysis of pooled data provide reliable estimates of FSD prevalence among females with type 1 diabetes.
To investigate the global prevalence of FSD, analyze the association between FSD risk and type 1 diabetes, and evaluate the predictors of FSD among females with type 1 diabetes.
The study search of the present systematic review was conducted through the Wanfang Database,
China National Knowledge Infrastructure, PubMed, and Embase from the inception date to February 28, 2023. Heterogeneity among the studies was analyzed with the Q and I2 tests. The sources of heterogeneity were detected through subgroup analyses and meta-regression.
Outcomes included the pooled prevalence of FSD among females with type 1 diabetes, the association between FSD risk and type 1 diabetes, and the predictors of FSD among females with type 1 diabetes.
The pooled prevalence of FSD among females with type 1 diabetes was 38.5% (95% CI, 32.1%-45.0%). The risk of FSD was higher in patients with type 1 diabetes than in healthy controls (odds ratio [OR], 3.77; 95% CI, 2.24-6.35). The significant predictors of FSD among females with type 1 diabetes were depression status (OR, 2.77; 95% CI, 1.29-5.93) and longer diabetes duration (OR, 1.19; 95% CI, 1.06-1.34).
Females with type 1 diabetes had a significantly increased prevalence of FSD, indicating that clinicians should be concerned about FSD among females with type 1 diabetes.
The strength of the present study is that it is the first systematic review and meta-analysis to investigate the global prevalence and predictors of FSD among females with type 1 diabetes. The limitation is that the results revealed significant heterogeneity after pooling the articles.
The present systematic review and meta-analysis revealed that the overall prevalence of FSD among females with type 1 diabetes was 38.5%, demonstrating a significant association between FSD risk and type 1 diabetes among females. Furthermore, we found that the significant predictors for FSD among females with type 1 diabetes were depression and a longer duration of diabetes.