背景:为了分析钙结合蛋白(S100A12)表达之间的关系,钙敏感受体(CaSR),膝关节骨关节炎(KOA)滑膜中的白细胞介素-7受体(IL-7R)和血管生成。
方法:收集2019年2月至2020年5月四川省人民医院收治的92例KOA患者的临床资料(KOA组,Kellgren-Lawrence分期:2级23例,3级49例,4级20例)。此外,选取本院同期治疗未受累的膝关节软骨正常患者87例。S100A12,CaSR,IL-7R,比较不同人群的微血管密度(MVD),以及S100A12、CaSR、IL-7R,MVD,并分析其对KOA的诊断价值。
结果:S100A12、CaSR、IL-7R,KOA组MVD明显高于对照组(P<0.05);S100A12、CaSR、4级患者的IL-7R明显高于2级和3级患者(P<0.05);S100A12、CaSR、IL-7R,MVD均呈正相关,差异有统计学意义(P<0.05)。根据接收机工作特性(ROC)曲线,S100A12、CaSR、和IL-7R用于KOA诊断分别为0.982、0.929和0.899。Youden指数分别为0.630、0.835、0.739。
结论:S100A12、CaSR、KOA滑膜中IL-7R显著上调,它们与血管生成密切相关。
BACKGROUND: To analyze the relationship between the expression of calcium binding protein (S100A12), calcium sensitive receptor (CaSR), and interleukin-7 receptor (IL-7R) in the synovium of knee osteoarthritis (KOA) and angiogenesis.
METHODS: The clinical data of 92 patients with KOA admitted to Sichuan Provincial People\'s Hospital from February 2019 to May 2020 were collected (KOA group, Kellgren-Lawrence staging: 23 cases of grade 2, 49 cases of grade 3, and 20 cases of grade 4). In addition, 87 cases of patients with normal knee cartilage that were not involved during the same period of treatment in this hospital were selected. The expressions of S100A12, CaSR, IL-7R, and microvascular density (MVD) were compared among different populations, and the correlation between S100A12, CaSR, IL-7R, and MVD, and its diagnostic value for KOA were analyzed.
RESULTS: The values of S100A12, CaSR, IL-7R, and MVD in the KOA group were significantly higher than those in the control group (P<0.05); the values of S100A12, CaSR, and IL-7R in grade 4 patients were significantly higher than those in grade 2 and 3 patients (P<0.05); S100A12, CaSR, IL-7R, and MVD were all positively correlated, and the difference was statistically significant (P<0.05). According to the receiver operating characteristic (ROC) curve, the area under the curve (AUC) of S100A12, CaSR, and IL-7R for KOA diagnosis was 0.982, 0.929, and 0.899, respectively. The Youden index was 0.630, 0.835, 0.739, respectively.
CONCLUSIONS: The expression levels of S100A12, CaSR, and IL-7R in the synovium of KOA are significantly up-regulated, and they are closely related to angiogenesis.