出生在广州队列研究(BIGCS)是一项大规模的前瞻性观察研究,调查社会的作用,在中国南方城市环境中,生物和环境对怀孕和儿童健康与发育的影响。居住在广州并在妊娠早期(<20周)到广州妇女儿童医疗中心(GWCMC)进行产前护理的孕妇有资格入选。2012年2月开始招募研究,总体参与率为76.3%。研究招募将持续到2018年12月,以实现30,000对母子的目标样本量。截至2016年4月30日,共收集了75,422份问卷,而14,696例活产,计划对队列儿童进行随访,直至18岁。在同一时期,共从参与者那里收集了1053,000个生物样本,包括产妇,父系和婴儿的血,脐带血,胎盘,脐带,以及母婴粪便样本。通过与常规健康和管理记录的记录链接,数据集得到了增强。我们计划将未来的记录与学校入学和国家考试记录联系起来。
The Born in Guangzhou Cohort Study (BIGCS) is a large-scale prospective observational study investigating the role of social, biological and environmental influences on pregnancy and child health and development in an urban setting in southern
China. Pregnant women who reside in Guangzhou and who attend Guangzhou Women and Children\'s Medical Center (GWCMC) for antenatal care in early pregnancy (<20 weeks\' gestation) are eligible for inclusion. Study recruitment commenced in February 2012, with an overall participation rate of 76.3%. Study recruitment will continue until December 2018 to achieve the target sample size of 30,000 mother-child pairs. At 30 April 2016, a total of 75,422 questionnaires have been collected, while 14,696 live births have occurred with planned follow-up of cohort children until age 18 years. During the same period a total of 1,053,000 biological samples have been collected from participants, including maternal, paternal and infant blood, cord blood, placenta, umbilical cord, and maternal and infant stool samples. The dataset has been enhanced by record linkage to routine health and administrative records. We plan future record linkage to school enrolment and national examination records.