背景:抑郁和焦虑症状通常在精神分裂症的整个进展过程中表现出来。然而,这些症状的患病率,除了它们的共同出现,仍然不确定,和临床相关因素仍然难以捉摸。
目的:本研究旨在调查精神分裂症患者中此类症状的患病率及其人口统计学和临床相关性。
方法:该研究包括根据ICD-10标准诊断为精神分裂症的19,623例患者。参与者来自2022年8月1日至10月30日在中国杭州当地卫生系统注册的社区居住患者。
结果:抑郁和焦虑症状的患病率,以及它们的共同出现,被确定为19%(95CI=18.5-19.6%),37.4%(95CI=36.8-38.0%),和17.7%(95CI=17.2-18.2%),分别。患者处方喹硫平,奥氮平,利培酮和利培酮的这些症状患病率显着降低(P<0.01)。Spearman相关分析显示抑郁症状与焦虑症状存在显著相关性(r=0.60,P=0.006)。此外,年龄,社会关系,睡眠状态与抑郁和焦虑症状显著相关,以及它们的共存,在单变量和多变量分析中。
结论:鉴于这些症状在精神分裂症患者中的普遍性和有害后果,强烈建议全面评估和实施有效的干预措施。
BACKGROUND: Depressive and anxiety symptoms commonly manifested throughout the progression of schizophrenia. However, the prevalence of these symptoms, alongside their co-occurrence, remains uncertain, and clinical correlates remain elusive.
OBJECTIVE: This study seeks to investigate the prevalence of such symptoms and their demographic and clinical associations among patients diagnosed with schizophrenia.
METHODS: The study included 19,623 patients diagnosed with schizophrenia based on the ICD-10 criteria. Participants were recruited from community-dwelling patients registered in the local health system in Hangzhou of
China between August 1 and October 30, 2022.
RESULTS: The prevalence rates of depressive and anxiety symptoms, as well as their co-occurrence, were determined to be 19 % (95%CI = 18.5-19.6 %), 37.4 % (95%CI = 36.8-38.0 %), and 17.7 % (95%CI = 17.2-18.2 %), respectively. Patients prescribed quetiapine, olanzapine, and risperidone exhibited significantly lower prevalence rates of these symptoms (P < 0.01). Spearman\'s correlation analysis revealed a significant correlation between depressive symptoms and anxiety symptoms (r = 0.60, P = 0.006). Additionally, age, social relationships, and sleep status were significantly associated with depressive and anxiety symptoms, and their co-occurrence, in both univariate and multivariate analyses.
CONCLUSIONS: Given the pervasive nature and detrimental consequences of these symptoms among individuals diagnosed with schizophrenia, comprehensive evaluation and implementation of efficacious interventions are highly recommended.