Pyogenic granuloma (PG) is a benign fibrovascular proliferative lesion on the skin and mucous membranes, but its pathogenesis remains unclear. PG usually occurs on the head and neck region, fingers and toes. The oral gingiva is the most common location for pregnant patients, while it is rarely found in the nasal cavity. This case is notable not only for its uncommon site and size but also for its gradual growth after delivery. Endoscopic surgery can achieve the desired cosmetic effect and a satisfactory airway. A rapidly growing hemorrhagic lesion in the nasal cavity should be considered as a differential diagnosis.

Pyogenic granuloma (PG) is a common vascular neoplasm in children. Data on 595 nm pulsed dye lasers for the treatment of PG in children remain scarce.
To summarize the clinical characteristics and to evaluate the effectiveness and safety of the 595 nm pulsed dye laser for the treatment of PG in children.
Retrospective case series.
A retrospective study was performed on 212 patients treated for PG with a 595 nm pulsed dye laser. SPSS version 19.0 was used for statistical analysis.
Among all 212 patients treated, 208 showed complete resolution of the lesion, and 4 dropped out after one treatment due to bleeding. A single treatment was sufficient in 139 (66.8%) patients, while two or three treatments were sufficient in 69 (33.2%) patients. Male patients responded better than female patients (χ2  = 7.603, p =0.006). Lesions in the nonorbital region responded better than those in the orbital region (χ2  = 7.445, p =0.006). The size of the lesion affected the effectiveness, and lesions with smaller diameters (t = -5.776, p <0.01) and heights (t = -10.368, p <0.01) showed better results.
Twelve patients (5.8%) were reported to have local complications and side effects, including edematous erythema, slight bleeding, hyperpigmentation, and hypopigmentation. The edematous erythema and slight bleeding disappeared gradually after several days. The localized pigment changes usually resolved spontaneously and disappeared completely after 6 months.
Our experience confirmed the efficacy and safety of the 595 nm pulsed dye laser for the treatment of PG in children.

暂无摘要。

Pyogenic granuloma is a benign growth characterized by active vascular proliferation and is prone to occurring during pregnancy. Given the complicated conditions of this special group of patients, it is controversial to perform removal therapy before delivery. Here, two giant pregnancy pyogenic granulomas of a patient at 34 weeks gestation were safely, completely and minimally invasively removed by water-cooled Nd: YAG laser without anesthetic agents, suturing or antibiotics. No recurrence was observed after 1 year. This removal therapy immediately relieved the problem of patient nutrition intake and greatly improved the quality of her prenatal preparation. Thus, this report highlights that complete excision of pyogenic granulomas during pregnancy can be performed before delivery when urgent circumstances are considered, and a water-cooled Nd: YAG laser can be applied as a powerful tool in this treatment.

Pyogenic granuloma (PG) is a common benign vascular proliferation which often occurs on the head, neck, hands, and feet. Among the various treatment options for PG, surgical excision is the most effective treatment which offers the lowest overall recurrence rates and also provides the exact diagnosis. However, it could have difficulties to do the surgery when lesions are located on the fingers and toes, especially very near to the nails, so laser may be a very good alternative choice. In this article, we evaluated the clinical efficacy and safety of neodymium-yttrium aluminum garnet (Nd:YAG) laser for treatment of PG located on the fingers and toes. Twenty-one patients with 21 PGs located on the fingers and toes were treated by multispot Nd-YAG laser. We chose monopulse (pulse width 10.5-13.5 ms; energy 100-125 J/cm2); treatment interval was 3-4 weeks. All lesions disappeared after one or two treatments. There was no apparent scar formation, no impact on the function of the fingers and toes, no damage to nail growth, and no recurrence in more than 12-month follow-up. Nd-YAG is an effective and safety treatment option for treatment of PG located on the fingers and toes.

Angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare chronic inflammatory disorder of unknown etiology that most commonly presents as painless lymphadenopathy or subcutaneous masses in the head and neck region. The pathogenesis of the disease is not yet clear. The differential diagnosis is determined using characteristic histological features, such as significant vascular proliferation, lymphocytes and eosinophil inflammation in the dermis. Here is presented the case of a patient with a solitary nodule of ALHE masquerading as pyogenic granuloma (PG). A 47 year-old male patient was admitted with an isolated lump on the right side of the back, which had been present for ~6 months; the nodule appeared to have characteristics of PG and was ~1.8×1.0 cm2 in diameter. To the best of our knowledge, this is the first case report regarding ALHE arising in the back. The present report discusses the manifestation, histopathological features and treatment of the case.

Pyogenic granuloma (PG) is an acquired benign vascular tumor of unknown etiology. In the present case report, PG was detected in a 49-year-old Chinese male patient with chronic plaque psoriasis. The psoriasis lesions on the finger where the granuloma had developed had been scratched excessively, as declared by the patient. No retinoid therapeutic agents were used during treatment. The patient responded poorly to cryotherapy and surgical curettage. However, following one session of 5-aminolevulinic acid photodynamic therapy (ALA-PDT), signs of improvement were demonstrated 1 week after the treatment, and 1 month following treatment, there were no signs of reoccurrence. Although a report demonstrating treatment success in one patient may be inadequate to estimate the true efficiency of ALA-PDT, dermatologists may consider ALA-PDT as an alternative therapy for stubborn PG.