■细胞移植作为帕金森病的治疗方法已经研究了几十年,干细胞可能是这种治疗最有前途的细胞来源。我们旨在研究干细胞移植是否有助于帕金森病的治愈,以及可能影响该疗法疗效的因素。
■PubMed,Embase,科克伦图书馆,WebofScience,SinoMed,中国国家知识基础设施(CNKI),中国科技期刊数据库(VIP),和ChinaInfo进行了彻底搜索,以寻找在帕金森病患者中进行干细胞移植的对照试验或随机对照试验。对合并效应进行分析,以95%置信区间评估加权平均差(WMD)。
■确定了9篇文章,其中包括129个人。干细胞移植是治疗帕金森病的有效方法(WMD=-14.86;95%CI:-16.62至-13.10;p<0.00001),神经干细胞,脐带间充质干细胞(UCMSCs),骨髓间充质干细胞(BMMSCs)是移植的有效细胞来源。干细胞移植可有效至少12个月,但由于监测患者超过1年的有限研究,其长期有效性仍然未知,更不用说几十年了。
■来自对照试验的数据表明,干细胞移植作为帕金森氏病的治疗方法可以有效至少12个月。可能影响其疗效的因素是移植后的时间和干细胞类型。
■(注册ID:CRD42022353145)。
UNASSIGNED: Cell transplants as a treatment for
Parkinson\'s disease have been studied for decades, and stem cells may be the most promising cell sources for this treatment. We aimed to investigate whether stem cell transplantation contributes to the cure for
Parkinson\'s disease and the factors that may influence the efficacy for this therapy.
UNASSIGNED: PubMed, Embase, Cochrane Library, Web of Science, SinoMed,
China National Knowledge Infrastructure (CNKI),
China Science and Technology Journal Database (VIP), and ChinaInfo were thoroughly searched to find controlled trials or randomized controlled trials performing stem cell transplantation in patients with Parkinson\'s disease. The pooled effects were analyzed to evaluate the weighted mean difference (WMD) with 95% confidence intervals.
UNASSIGNED: Nine articles were identified including 129 individuals. Stem cell transplantation was an effective treatment for
Parkinson\'s disease (WMD = -14.86; 95% CI: -16.62 to -13.10; p < 0.00001), with neural stem cells, umbilical cord mesenchymal stem cells (UCMSCs), and bone marrow mesenchymal stem cells (BMMSCs) being effective cell sources for transplantation. Stem cell transplantation can be effective for at least 12 months, but its long-term effectiveness remains unknown due to the limited studies monitoring patients for more than 1 year, not to mention decades.
UNASSIGNED: Data from controlled trials suggest that stem cell transplantation as a therapy for Parkinson\'s disease can be effective for at least 12 months. The factors that may influence its curative effect are time after transplantation and stem cell types.
UNASSIGNED: (Registration ID: CRD42022353145).