背景:鼻内镜手术(ESS)可显著改善慢性鼻-鼻窦炎(CRS)患者的嗅觉功能。本研究旨在进行荟萃分析,以评估ESS对CRS患者嗅球体积(OBV)的影响。
方法:对PubMed,Medline,Embase,WebofScience,和其他数据库进行了鉴定,以利用磁共振成像评估CRS患者ESS后OBV变化的研究.
结果:共纳入4项研究,共168名参与者。比较CRS患者手术前后3-6个月OBV的变化,ESS显著提高了总体OBV(P=0.005,I2=66%),左侧OBV增加5.57mm3(P=0.84,I2=0%),右侧OBV增加8.63mm3(P=0.09,I2=53%)。在ESS后3-6个月,健康对照和CRS患者之间OBV的差异仍然存在。ESS后CRS患者的总体OBV明显小于对照组(平均差=-3.84,P=0.04),左侧平均差为4.13mm3(P=0.72,I2=0%),右侧平均差为3.22mm3(P=0.0001,I2=89%)。
结论:ESS显著增加CRS患者的OBV。
BACKGROUND: Endoscopic sinus surgery (ESS) could significantly improve olfactory function among patients with chronic rhinosinusitis (CRS). This study aimed to perform a meta-analysis to evaluate the effect of ESS on the olfactory bulb volume (OBV) among patients with CRS.
METHODS: A systemic search of PubMed, Medline, Embase, Web of Science, and other databases was conducted to identify studies assessing OBV changes in patients with CRS after ESS utilizing magnetic resonance imaging.
RESULTS: A total of four studies with 168 participants were included. Comparing the changes in OBV of patients with CRS before and after surgery within 3-6 months, the ESS significantly improved the overall OBV (P = 0.005, I2 = 66%), with the left OBV increased by 5.57mm3 (P = 0.84, I2 = 0%), and the right OBV increased by 8.63mm3 (P = 0.09, I2 = 53%). A difference in OBV persists between healthy controls and patients with CRS 3-6 months after ESS. The overall OBV of patients with CRS after ESS was significantly smaller than controls (mean difference = -3.84, P = 0.04), with a mean difference of 4.13mm3 on the left side (P = 0.72, I2 = 0%), and a mean difference of 3.22mm3 on the right side (P = 0.0001, I2 = 89%).
CONCLUSIONS: ESS significantly increases the OBV among patients with CRS.