■脑肿瘤,尤其是神经胶质瘤,以高杀伤力而闻名。目前了解到肿瘤与凝血和炎症的相关性已经逐渐被揭示。
■本研究旨在尽可能全面地探索几种已报告的外周血参数的潜在价值,术前诊断和识别脑肿瘤(重点是胶质瘤)。
■中枢神经系统肿瘤患者(颅咽管瘤,室管膜瘤,脊髓脑膜瘤,听神经瘤,脑转移瘤,脑膜瘤,和神经胶质瘤)或原发性三叉神经痛入院进行回顾性分析。常规凝血因子试验结果,血清白蛋白试验,并在入院时记录各组患者的外周血中的血细胞检测。中性粒细胞-淋巴细胞比率(NLR),派生NLR(dNLR),血小板-淋巴细胞比率(PLR),淋巴细胞-单核细胞比率(LMR),预后营养指数(PNI),全身免疫炎症指数(SII),泛免疫炎症值(PIV),并计算了它们的配对。分析了他们识别脑肿瘤的能力及其与胶质瘤分级的相关性。
■本回顾性病例对照研究共纳入698例患者。胶质瘤患者有较高的NLR,SII,和PIV,但LMR较低。脑转移组的NLR低于对照组,脑膜瘤,和听神经瘤组,但SII和PIV高于室管膜瘤组。纤维蛋白原,白细胞计数,中性粒细胞计数,NLR,SII,GBM组PIV高于对照组。在所有比较中,NLR和NLR+dNLR显示出最大的准确性,曲线下面积(AUC)为0.7490(0.6482-0.8498)和0.7481(0.6457-0.8505),分别。PIV,dNLR+PIV,LMR+PIV排名第二,AUC为0.7200(0.6551-0.7849),0.7200(0.6526-0.7874),0.7204(0.6530-0.7878)和0.7206(0.6536-0.7875),分别。
■NLR,PIV,它们的组合在脑肿瘤的诊断中显示出很高的敏感性和特异性,尤其是神经胶质瘤.总的来说,我们的结果为这些方便可靠的外周血标志物提供了证据.
UNASSIGNED: Brain tumors, especially gliomas, are known for high lethality. It is currently understood that the correlations of tumors with coagulation and inflammation have been gradually revealed.
UNASSIGNED: This study aimed to explore the potential value of several reported peripheral blood parameters as comprehensively as possible, with preoperative diagnosis and identification of brain tumors (focus on gliomas).
UNASSIGNED: Patients with central nervous system tumors (craniopharyngioma, ependymoma, spinal meningioma, acoustic neuroma, brain metastases, meningioma, and glioma) or primary trigeminal neuralgia admitted to our hospital were retrospectively analyzed. The results of the routine coagulation factor test, serum albumin test, and blood cell test in peripheral blood were recorded for each group of patients on admission. Neutrophil-lymphocyte ratio (NLR), derived NLR (dNLR), platelet-lymphocyte ratio (PLR), lymphocyte-monocyte ratio (LMR), prognostic nutritional index (PNI), the systemic immune-inflammation index (SII), pan-immune-inflammation value (PIV), and their pairings were calculated. Their ability to identify brain tumors and their correlation with glioma grade were analyzed.
UNASSIGNED: A total of 698 patients were included in this retrospective case-control study. Glioma patients had higher NLR, SII, and PIV but lower LMR. The NLR in the brain metastasis group was lower than that in the control, meningioma, and acoustic neuroma groups, but the SII and PIV were higher than those in the ependymoma group. Fibrinogen, white blood cell count, neutrophil count, NLR, SII, and PIV in the GBM group were higher than those in the control group. In all comparisons, NLR and NLR + dNLR showed the greatest accuracy, with areas under the curve (AUCs) of 0.7490 (0.6482-0.8498) and 0.7481 (0.6457-0.8505), respectively. PIV, dNLR + PIV, and LMR + PIV ranked second, with AUCs of 0.7200 (0.6551-0.7849), 0.7200 (0.6526-0.7874), 0.7204 (0.6530-0.7878) and 0.7206 (0.6536-0.7875), respectively.
UNASSIGNED: NLR, PIV, and their combinations show high sensitivity and specificity in the diagnosis of brain tumors, especially gliomas. Overall, our results provide evidence for these convenient and reliable peripheral blood markers.