Osteochondral autologous transplantation

  • 文章类型: Journal Article
    关于从距骨局部非负重关节面获取骨软骨自体移植(OAT)治疗距骨骨软骨病变(OLTs)的临床结果的研究很少。这项研究的目的是回顾我们的患者的短期到中期结果,这些患者从同侧距骨关节小平面收获OAT治疗OLT。
    2010年12月至2018年11月,24名患者被纳入本研究。男性16例,女性8例,平均年龄39.1岁,随访时间50.9个月。根据美国骨科足踝协会(AOFAS)踝足-后足评分和视觉模拟评分(VAS)评分对临床结果进行评估。术前平片和磁共振成像(MRI)扫描,术后X光片,最后随访时进行X线和计算机断层扫描(CT)扫描。
    AOFAS评分从术前61.3±19.0显著改善至术后84.9±9.2(P<0.001)。末次随访时VAS评分由6.1±2.3提高至2.0±1.4(P<0.001)。21例患者(87.5%)对其临床结果感到满意。最后一次CT扫描,三名患者的供体部位有骨囊肿形成,五名患者的受体部位和五名患者的两个部位。两名患者(8.3%)由于内侧沟肥厚性软组织撞击而接受了关节镜清理术的再次手术。
    从同侧距骨关节小关节收获OAT显示令人满意的结果。术后平均VAS评分和AOFAS踝足-后足评分明显改善。术后截骨部位周围撞击是索引程序后再次手术的主要并发症和原因。此外,在CT下发现受体和/或供体部位的骨囊肿有很大比例。因此,需要更长时间的随访才能确定该技术的长期临床结果.
    There are few studies on the clinical outcomes of osteochondral autologous transplantation (OAT) harvesting from local talar non-weight-bearing articular facets for the treatment of osteochondral lesions of the talus (OLTs). The purpose of this study was to review the short- to midterm outcomes of our patients who were treated with OAT harvesting from ipsilateral talar articular facets for OLTs.
    Between December 2010 and November 2018, 24 patients were enrolled in this study. There were 16 males and eight females with an average age of 39.1 years and a follow-up period of 50.9 months. The clinical results were evaluated according to the American Orthopedic Foot & Ankle Society (AOFAS) ankle-hindfoot score and the visual analogue scale (VAS) score. Pre-operative plain radiographs and magnetic resonance imaging (MRI) scans, post-operative radiographs, and X-ray and computed tomography (CT) scans at the last follow-up were observed.
    There was a significant improvement in the AOFAS score from 61.3 ± 19.0 pre-operatively to 84.9 ± 9.2 post-operatively (P < 0.001). The VAS score improved from 6.1 ± 2.3 to 2.0 ± 1.4 at the last follow-up (P < 0.001). Twenty-one patients (87.5%) were satisfied with their clinical results. By the last follow-up CT scan, there was bone cyst formation at the donor sites in three patients, at the recipient sites in five patients and at both sites in five patients. Two patients (8.3%) underwent re-operation with arthroscopic debridement because of medial gutter hypertrophic soft tissue impingement.
    OAT harvesting from the ipsilateral talar articular facet showed satisfactory results. The mean post-operative VAS score and AOFAS ankle-hindfoot score improved significantly. Post-operative impingement around the osteotomy site was the main complication and reason for re-operation after the index procedure. In addition, bone cysts at the recipient and/or donor site(s) were found with a large percentage under CT. Therefore, longer follow-up is necessary to determine the long-term clinical results for this technique.
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  • 文章类型: Journal Article
    背景:接受膝关节镜检查的患者中有超过19%的患者患有关节软骨缺损。软骨或骨软骨损伤对膝关节功能和患者生活质量有负面影响。然而,由于透明软骨不可再生,治疗仍具有挑战性.这项研究的目的是系统分析随机对照试验的数据,以比较骨软骨自体移植(OAT)和微骨折(MF)手术的术后结局。我们假设OAT的结果比MF程序更好。
    方法:对EMBASE进行系统的文献检索,Pubmed,Cochrane图书馆数据库是根据PRISMA(系统审查和荟萃分析的首选报告项目)指南进行的。结果衡量标准包括:优秀率或良好率,体育的回报率,故障率,骨关节炎发病率,国际软骨修复协会(ICRS)评分,Lysholm膝盖评分,和Tegner规模。统计分析是使用审查经理(RevMan,5.3版)软件。
    结果:系统搜索确定了7项研究,共346例患者。汇总结果显示,两组在运动回报率和失败率上存在显着差异。以下结果评分显示显着改善(术前与术后):Lysholm评分(p=0.02),Tegner量表(p<0.00001),和ICRS评分(p<0.00001)。在优、良、骨性关节炎得率方面差异不显著。
    结论:OAT组的患者可以更快地恢复比赛,与MF组相比,甚至恢复到损伤前的活动水平。根据Lysholm评分,OAT优于MF程序,Tegner得分,ICRS评分,和失败率。然而,很少有研究报告了长期结局,也没有安全重返运动的统一标准.需要进一步的研究。
    方法:二级,随机对照试验的荟萃分析。
    BACKGROUND: More than 19% of patients undergoing knee arthroscopies suffers from articular cartilage defects. The chondral or osteochondral lesion has negative impacts on the knee joints function and the life quality of patients. However, the treatment remains challenging as hyaline cartilage is not renewable. The purpose of this study was to systematically analyze the data of randomized controlled trials for comparing the postoperative outcomes between osteochondral autologous transplantation (OAT) and microfracture (MF) procedure. We hypothesized that the outcomes were better in OAT than MF procedure.
    METHODS: A systematic literature search of the EMBASE, Pubmed, and Cochrane Library databases was conducted based on PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. The outcome measures include: the rate of excellent or good results, the rate of return to sports, the failure rate, osteoarthritis rate, International Cartilage Repair Society (ICRS) score, Lysholm Knee Score, and Tegner scale. The statistical analysis was completed using Review Manager (RevMan, version 5.3) software.
    RESULTS: The systematic search identified 7 studies with a total of 346 patients. The pooled result showed significant differences between the two groups in the rate of return to sports and failure. The following outcome scores showed significant improvement (pre- vs postoperatively): Lysholm score (p = 0.02), Tegner scale (p < 0.00001), and ICRS score (p < 0.00001). The differences were not significant in the excellent or good results and the rate of osteoarthritis.
    CONCLUSIONS: The patients in OAT group may return to play quicker, even return to pre-injury level of activity compared to the MF group. OAT is better than MF procedure in accordance with Lysholm score, Tegner score, ICRS score, and the rate of failure. However, few studies have reported long-term outcomes and there has no uniform criteria for safe return to sports. Further research is needed.
    METHODS: Level II, meta-analysis of randomized controlled trials.
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