目的:鼻窦嗜酸细胞乳头状瘤(SOP)是一种少见的鼻窦乳头状瘤亚型。目前很少有关于内镜手术切除后其临床特征和结果的报道。本研究旨在通过单中心回顾性病例系列分析,探讨SOP的临床特点及预测肿瘤复发的潜在因素。
方法:我们对2012年6月至2019年4月接受SOP内镜手术的69例患者进行了回顾性分析。患者的人口统计数据,临床特征,随访期,并收集治疗结果.
结果:该系列包括43名男性和26名女性,平均年龄为60.2岁。肿瘤通常累及鼻腔(n=59;89.4%),其次是上颌窦(n=31;44.9%),筛窦(n=28;40.6%),额窦(n=6;8.7%)和蝶窦(n=6;8.7%)。随访时间3个月至96个月(平均34.6个月),9例患者(13%)在随访期间发生了肿瘤复发。单因素分析发现,SOP复发与肿瘤附着部位显著相关,大川肿瘤分期,和组织学发育不良(p<0.05)。多因素COX回归分析发现Oikawa分期系统(p=0.024)和异型增生(p=0.04)与肿瘤复发显著相关。
结论:SOP的复发率与内镜时代的鼻窦内翻性乳头状瘤相当。我们的发现还表明,发育不良的存在是无复发生存的独立预后因素。
OBJECTIVE: Sinonasal oncocytic papilloma (SOP) is a rare subtype of sinonasal papilloma. There are currently few reports on its clinical features and outcomes after endoscopic surgical resection. This study aims to explore the clinical characteristics of SOP and potential factors predicting tumor recurrence through a single-center retrospective case series analysis.
METHODS: We conducted a retrospective analysis of 69 patients who underwent endoscopic surgery of SOP from June 2012 to April 2019. The data of patients\' demographics, clinical features, follow-up period, and treatment outcomes were collected.
RESULTS: The series includes 43 males and 26 females with an average age of 60.2 years. The tumor commonly involved the nasal cavity (n = 59; 89.4%), followed by maxillary sinus (n = 31; 44.9%), ethmoid sinus (n = 28; 40.6%), frontal sinus (n = 6; 8.7%) and sphenoid sinus (n = 6; 8.7%). The follow-up period ranged from 3 months to 96 months (mean, 34.6 months) and nine patients (13%) developed tumor recurrence during the follow-up period. Univariate analysis found that the recurrence of SOP was significantly related to tumor attachment site, Oikawa tumor stage, and histological dysplasia (p<0.05). Multivariate COX regression analysis found that Oikawa staging system (p = 0.024) and presence of dysplasia (p = 0.04) were significantly related to tumor recurrence.
CONCLUSIONS: SOP had low recurrence rate which was comparable to sinonasal inverted papilloma in the endoscopic era. Our findings also demonstrated that presence of dysplasia is an independent prognostic factor for recurrence free survival.