背景:NINDS-加拿大卒中网络(NINDS-CSN)推荐了一种由三种方案组成的神经心理学电池来诊断血管性认知障碍(VCI),然而,由于文化和语言的差异,该电池不能直接在中国使用。缺乏普通话电池的验证。我们的研究调查了适用于VCI可能性较高的中风患者的电池的中文版本的信度和效度。
方法:50名轻度卒中患者(美国国立卫生研究院卒中量表[NIHSS]评分中位数,2)和50名无卒中正常对照。所有主题\'人口统计学,临床病史,记录卒中严重程度.NINDS-CSN神经心理学协议被改编成中文版本。外部有效性,定义为方案汇总评分区分卒中患者与对照组的能力,使用接受者工作特性曲线的曲线下面积(AUC)确定。我们还评估了内部一致性和评估者内部可靠性。
结果:在所有三种方案中,卒中患者的表现明显低于对照组(F统计量在24.9和31.4之间,P<0.001)。AUC评估的外部效度为0.88(95%置信区间[CI],0.81-0.95),0.88(95%CI,0.81-0.94),60分钟为0.86(95%CI,0.79-0.94),30分钟和5分钟协议,分别。所有受试者的Cronbach的认知测试α为0.87。在60分钟的组内相关系数为0.90、0.83和0.75的情况下,评级器内部可靠性是可以接受的,30分钟和5分钟协议,分别。
结论:三种NINDS-CSN神经心理学方案的中文版适用于评估中国轻度卒中患者的VCI是有效且可靠的。
BACKGROUND: The NINDS-Canadian Stroke Network (NINDS-CSN) recommended a neuropsychological battery of three protocols to diagnose vascular cognitive impairment (VCI), however, due to culture and language differences, the battery cannot be directly used in
China. Validation of the battery in mandarin Chinese is lacking. Our study investigated the reliability and validity of the adapted Chinese versions of the battery in stroke patients with high probability of VCI.
METHODS: Fifty mild stroke patients (median of National Institute of Health Stroke Scale [NIHSS] score, 2) and 50 stroke-free normal controls were recruited. All subjects\' demographics, clinical history, and stroke severity were recorded. The NINDS-CSN neuropsychological protocols were adapted into the Chinese versions. External validity, defined as the ability of the protocol summary scores to differentiate stroke patients from controls, was determined using the area under the curve (AUC) of the receiver operating characteristics curve. We also evaluated internal consistency and intra-rater reliability.
RESULTS: Stroke patients performed significantly poorer than controls on all three protocols (F statistics between 24.9 and 31.4, P < 0.001). External validity evaluated by AUCs was 0.88 (95% confidence interval [CI], 0.81-0.95), 0.88 (95% CI, 0.81-0.94), and 0.86 (95% CI, 0.79-0.94) for the 60-min, 30-min and 5-min protocols, respectively. Cronbach\'s alpha of the cognitive tests was 0.87 for all subjects. Intra-rater reliability was acceptable with intraclass correlation coefficients 0.90, 0.83 and 0.75 for the 60-min, 30-min and 5-min protocols, respectively.
CONCLUSIONS: The adapted Chinese versions of three NINDS-CSN neuropsychological protocols were valid and reliable for assessing VCI in Chinese patients with mild stroke.