Cinnamomumzeylanicum是一种传统的药用植物,以其抗炎作用而闻名,抗糖尿病药,抗菌,抗癌,和抗氧化性能。使用纳米混悬剂治疗感染性疾病的疗效尚不清楚。这项研究旨在评估生物活性,生化表征,和新制备的C.zeylanicum纳米悬浮液的生物利用度。泽兰的结构、生化特性及其生物活性,如抗氧化剂,抗菌药物,抗糖基化,α-淀粉酶抑制,使用傅里叶变换红外(FTIR)光谱和高效液相色谱(HPLC)进行细胞毒性。C.zeylanicum提取物和纳米悬浮液显示的TPC值为341.88和39.51mgGAE/100g,而TFC为429.19和239.26mgCE/100g,分别。泽兰提取物和纳米混悬剂的DPPH抑制潜力分别为27.3%和10.6%,分别。生物膜抑制活性表明,树皮提取物和纳米悬浮液对大肠杆菌表现出过度的生长抑制作用,分别达到67.11%和66.09%,分别。提取物和纳米混悬剂的α-淀粉酶抑制率分别为39.3%和6.3%,而纳米混悬剂和提取物的抗糖基化活性分别为42.14%和53.76%,分别。提取物和纳米悬浮液显示最大溶血分别为54.78%和19.89%,分别。结果表明,纳米悬浮液具有抗糖尿病,抗菌,抗癌,和抗氧化性能。进一步研究,然而,需要评估纳米混悬剂治疗用途的临床研究。
Cinnamomum zeylanicum is a traditional medicinal plant known for its anti-inflammatory, antidiabetic, antimicrobial, anticancer, and antioxidant properties. Its therapeutic efficacy using
nanosuspensions is still unclear for treating infectious diseases. This study was designed to evaluate the bioactivities, biochemical characterization, and bioavailability of freshly prepared nanosuspensions of C. zeylanicum. Structural and biochemical characterization of C. zeylanicum and its biological activities, such as antioxidants, antimicrobials, antiglycation, α-amylase inhibition, and cytotoxicity was performed using Fourier-transform infrared (FTIR) spectroscopy and High-Performance Liquid Chromatography (HPLC). C. zeylanicum extract and
nanosuspensions showed TPCs values of 341.88 and 39.51 mg GAE/100 g while showing TFCs as 429.19 and 239.26 mg CE/100g, respectively. DPPH inhibition potential of C. zeylanicum extract and nanosuspension was 27.3% and 10.6%, respectively. Biofilm inhibition activity revealed that bark extract and nanosuspension showed excessive growth restraint against Escherichia coli, reaching 67.11% and 66.09%, respectively. The α-amylase inhibition assay of extract and nanosuspension was 39.3% and 6.3%, while the antiglycation activity of nanosuspension and extract was 42.14% and 53.76%, respectively. Extracts and
nanosuspensions showed maximum hemolysis at 54.78% and 19.89%, respectively. Results indicated that
nanosuspensions possessed antidiabetic, antimicrobial, anticancer, and antioxidant properties. Further study, however, is needed to assess the clinical studies for the therapeutic use of
nanosuspensions.