未经证实:为了研究创伤后应激障碍(PTSD)患者和创伤暴露受试者的情绪和记忆相关脑区的动态变化,谁经历了机动车事故(MVA)。
UNASSIGNED:功能磁共振成像(fMRI)和一般数据是从2天内经历过MVA的创伤受害者收集的,并对其社会支持和应对方式进行评价。PTSD精神疾病诊断和统计手册-第五版(PCL-5)用于筛查和诊断。随后,17名PTSD患者和23名车祸创伤暴露者在2个月时完成了第二次fMRI扫描。通过使用基于体素的形态计量学(VBM)来分析数据,以检查相关大脑区域的体积变化。相关性分析用于评估感兴趣区域(ROI)与临床量表总分之间的相关性。随后,研究了PCL-5总分与简化应对方式问卷(SCSQ)和社会支持率量表(SSRS)个体维度之间的关系。
UNASSIGNED:与对照组相比,结果显示,2个月时,PTSD组右侧SFG体积减少.同样,PTSD组的一项比较显示,2个月时左侧STG体积减少.与对照组相比,PTSD患者表现出更消极的应对方式,在客观和主观支持方面表现较差。此外,PCL-5总分与积极应对呈负相关,客观支持,主观支持。
UNASSIGNED:PTSD的发生可能与右侧SFG和左侧STG的体积减少有关,并且PTSD患者获得的社会支持较少,并且在面对压力事件时倾向于以消极的方式应对。这些结果表明,在MVA的2个月内,在患有PTSD的人的某些大脑区域发生了灰质体积的变化。我们相信我们的研究结果将为PTSD的神经心理学机制提供有用的见解。
UNASSIGNED: To investigate the dynamic changes of emotional and memory-related brain regions in post-traumatic stress disorder (PTSD) patients and trauma-exposed subjects, who experienced motor vehicle accident (MVA).
UNASSIGNED: Functional Magnetic Resonance imaging (fMRI) and general data were collected from trauma victims who had experienced MVA within 2 days, and their social support and coping style were evaluated. The PTSD Checklist for Diagnostic and Statistical Manual of Mental Disorders-Fifth Edition (PCL-5) is used for screening and diagnosis. Subsequently, 17 PTSD patients and 23 car accident trauma-exposed individuals completed a second fMRI scan at 2 months. Data were analyzed by using voxel-based morphometry (VBM) to examine the volume changes of relevant brain regions. Correlation analysis was used to assess the correlation between the regions of interest (ROIs) and the total scores on the clinical scales. Subsequently, the relationship between the total PCL-5 scores and the individual dimensions of the Simplified Coping Style Questionnaire (SCSQ) and the Social Support Rate Scale (SSRS) was studied.
UNASSIGNED: In comparison with the control group, the results showed a reduction in right SFG volume in the PTSD group at 2 months. Similarly, a comparison within the PTSD group revealed a reduction in the left STG volume at 2 months. Compared with the control group, PTSD patients showed a more negative coping style and worse performance in objective and subjective support. In addition, the total PCL-5 scores were negatively associated with positive coping, objective support, and subjective support.
UNASSIGNED: The occurrence of PTSD may be related to reduced volume of the right SFG and left STG, and that patients with PTSD receive less social support and tend to cope in a negative manner in the face of stressful events. These results suggest that within 2 months of the MVA, changes in gray matter volume have occurred in some brain regions of those suffering from PTSD. We believe the results of our study will provide useful insights into the neuropsychological mechanisms underlying PTSD.