这项研究的目的是评估局部组合的莫西丁3.5%的疗效,10%吡虫啉和10%吡喹酮用于预防Dirofilariaimmitis(Leidy,1856)狗的感染。为此,一项随机对照临床试验于2021年8月至2022年10月在Goiana市进行,伯南布哥州,巴西东北部,心丝虫非常普遍。在最初采样的213只狗中(基线),68例(31.9%)成人抗原阳性(SNAP4DxPlus,Idexx)和/或微丝虫(改良的Knott\'s测试)。第0天,将140只阴性犬随机分为治疗组和对照组,每个70只动物。在研究期间,出于不同的原因,取出60只狗(34只处理的和26只未处理的)。在研究结束时(第360±2天),对36个处理的和44个未处理的取样并包括在功效计算中。对成虫和微丝虫发育的疗效为84.7%,只有一只接受治疗的狗对成年抗原呈阳性,但对微丝菌呈阴性。另一方面,八只未经治疗的狗对成年抗原和/或微丝虫呈阳性,导致组间阳性数量存在显著差异(卡方检验=4.706,df=1,P=0.0301)。值得注意的是,对微丝虫出现的疗效为100%(即,所有治疗的狗均为阴性),三只未经治疗的狗对微丝虫呈阳性。局部联合使用3.5%的莫西丁,与未经治疗的狗相比,10%吡虫啉和10%吡喹酮显着降低了接受治疗的狗感染D.immitis的风险。在巴西东北部一个高度流行的地区。
The aim of this study was to evaluate the efficacy of a topical combination of moxidectin 3.5%, imidacloprid 10% and praziquantel 10% for the prevention of Dirofilaria immitis (Leidy, 1856) infection in dogs. For this purpose, a randomized and controlled clinical trial was conducted between August 2021 and October 2022, in the municipality of Goiana, state of Pernambuco, north-eastern Brazil, where heartworm is highly prevalent. Of the 213 dogs initially sampled (baseline), 68 (31.9%) were positive for adult antigens (SNAP 4Dx Plus, Idexx) and/or microfilariae (modified Knott\'s test). On day 0, 140 negative dogs were randomly included in the treatment and control groups, 70 animals each. During the study, 60 dogs (34 treated and 26 untreated) were removed for different reasons. At the end of the study (day 360 ± 2), 36 treated and 44 untreated were sampled and included in the efficacy calculation. The efficacy against the development of adults and
microfilariae was 84.7%, with only one treated dog being positive for adult antigens but negative for
microfilariae. On the other hand, eight untreated dogs were positive for adult antigens and/or
microfilariae, resulting in a significant difference in the number of positives between groups (Chi-square test = 4.706, df = 1, P = 0.0301). Remarkably, the efficacy against the appearance of D. immitis
microfilariae was 100% (i.e., all treated dogs negative) and three untreated dogs were positive for
microfilariae. The topical combination of moxidectin 3.5%, imidacloprid 10% and praziquantel 10% significantly reduced the risk of D. immitis infection in treated dogs as compared with untreated dogs, in a highly endemic area in north-eastern Brazil.