未经证实:混合性神经内分泌非神经内分泌肿瘤(MiNEN)是一种极为罕见的实体,由神经内分泌和非神经内分泌成分组成。它可以发生在全身的各种器官中,发病率上升。它的临床管理是一个快速增长的兴趣领域;然而,大规模的患者队列仍然缺乏指导临床实践。
未经评估:人口统计,临床病理,以及在国家监测中诊断为MiNEN的所有患者的生存信息,流行病学,提取和最终结果(SEER)计划数据库(2000-2017年)并进行进一步分析。对患者2010年前后的资料进行比较,了解MiNEN的流行病学变化。比较了MINEN起源于不同器官的特征。还分析了手术切除转移性MiNENs的临床意义。
未经评估:共筛查了1081名患者,在应用排除标准之后,最后对767例患者进行分析。没有明显的性别偏好(49.2%vs50.8%,p>0.05),大多数患者为白种人(n=627,81.7%)。共有88.3%的患者年龄在50岁以上,中位年龄为60岁。79.3%的肿瘤位于远端消化道,和67.7%为3/4级。33.9%的患者在诊断时出现远处转移。总共88%的患者接受了手术治疗。在2000年至2017年期间,患者人数增加了10倍。性别没有显著差异,种族,舞台,或2010年前后诊断的患者的手术治疗。2010年以后,更多60岁以上的患者被确诊(p=0.009)。整个队列的中位生存期为61.0±9.8个月。经过多变量分析,年龄较大(>60岁,p<0.01),更晚期(p<0.01),3/4级(p<0.01),和非手术治疗(p<0.01)是生存率较差的独立危险因素。阑尾MiNENs显示最佳预后。进一步分析了总共260个转移性MINENs。只有源自阑尾的转移性MiNENs患者有可能从手术切除中获益。与其他网站相比(p=0.05)。
未经评估:这项研究提供了流行病学,临床病理,和最大数量的MINEN患者的生存信息。虽然MiNEN是一种极为罕见的恶性肿瘤,其发病率迅速增加。大多数患者患有晚期疾病,这凸显了未来改进早期检测的必要性。附录是MiNEN最常见的主要站点,手术切除部分源自阑尾的转移性MiNEN具有良好的生存结局。
UNASSIGNED: Mixed neuroendocrine non-neuroendocrine neoplasm (
MiNEN) is an extremely rare entity, consisting of neuroendocrine and non-neuroendocrine components. It can occur in various organs throughout the body, with a rising incidence. Its clinical management is a rapidly growing field of interest; however, large-scale patient cohorts are still missing to guide clinical practice.
UNASSIGNED: The demographic, clinicopathological, and survival information of all patients diagnosed with
MiNEN in the national Surveillance, Epidemiology, and End Results (SEER) program database (2000-2017) were extracted and further analyzed. The information of the patients before and after 2010 was compared to understand the epidemiological changes of MiNEN. The characteristics of
MiNEN originating in different organs were compared. The clinical significance of surgical resection for metastatic MiNENs was also analyzed.
UNASSIGNED: A total of 1081 patients were screened, and after applying the exclusion criteria, 767 patients were finally analyzed. There was no obvious sex preference (49.2% vs 50.8%, p>0.05) and the majority of the patients were Caucasians (n=627, 81.7%). A total of 88.3% of the patients were older than 50 years old, and the median age was 60 years. 79.3% of the tumors are located in the distal digestive tract, and 67.7% were grade 3/4. Distant metastasis was presented in 33.9% of the patients at diagnosis. A total of 88% of the patients underwent surgical treatments. The number of patients increased 10-fold between 2000 and 2017. There was no significant difference in sex, race, stage, or surgical treatments among the patients diagnosed before and after 2010. More patients older than 60 years were diagnosed after 2010 (p=0.009). The median survival was 61.0 ± 9.8 months for the whole cohort. After multivariate analysis, older age (>60 years, p<0.01), more advanced stage (p<0.01), grade 3/4 (p<0.01), and non-surgical treatment (p<0.01) were independent risk factors for poorer survival. The appendiceal MiNENs showed the best prognosis. A total of 260 metastatic MiNENs were further analyzed. Only patients with metastatic MiNENs originating from the appendix had a potential benefit from surgical resection, compared to other sites (p=0.05).
UNASSIGNED: This study provides the epidemiological, clinicopathological, and survival information of the largest number of MiNEN patients. Although
MiNEN is an extremely rare malignant neoplasm, its incidence increases rapidly. The majority of the patients suffered from advanced-stage disease, which highlights the need for improvement of early detection in the future. The appendix is the most common primary site of MiNEN, and surgical resection for selected metastatic
MiNEN originating in the appendix has favorable survival outcomes.