Metacarpophalangeal Joint

掌指关节
  • 文章类型: Journal Article
    背景:滑雪者的拇指是拇指掌指关节尺侧副韧带的一种损伤,这可能导致骨骼破碎和关节不稳定。
    目的:本研究的目的是比较传统的克氏针固定方法与U形克氏针固定方法治疗移位的小骨片,旋转,或者滑雪者骨折不稳定。
    方法:对2019年1月至2021年12月天津医院收治的30例滑雪者拇指患者进行回顾性研究。将患者分为两组:A组接受传统的克氏针固定,B组接受U形克氏针固定。评估围手术期的功能评估和并发症。
    结果:两种手术方法均可明显减轻术后疼痛,增加关节活动范围。与A组相比,B组在随访期间疼痛发生率较低,并且在Tip-pinch和Grip测试中显示出显着的功能改善。U形克氏针固定在围手术期明显减少了并发症。
    结论:U形克氏针内固定治疗拇指近端指骨基尺侧撕脱骨折安全有效。
    BACKGROUND: Skier\'s thumb is a type of injury to the ulnar collateral ligament of the metacarpophalangeal joint of the thumb, which can result in bone fragmentation and joint instability.
    OBJECTIVE: The objective of this study was to compare the traditional Kirschner wire fixation method with the U-shaped Kirschner wire method for treating small bone fragments with displacement, rotation, or instability in skier\'s fractures.
    METHODS: A retrospective study was conducted on 30 patients with skier\'s thumb who were treated at Tianjin Hospital from January 2019 to December 2021. Patients were divided into two groups: Group A received traditional Kirschner wire fixation, while Group B received U-shaped Kirschner wire fixation. Functional assessments and complications during the perioperative period were evaluated.
    RESULTS: Both surgical methods significantly reduced postoperative pain and increased joint range of motion. Group B had a lower incidence of pain during follow-up and showed significant functional improvement in Tip-pinch and Grip tests compared to Group A. U-shaped Kirschner wire fixation significantly reduced complications during the perioperative period.
    CONCLUSIONS: The U-shaped Kirschner wire internal fixation is a safe and effective treatment for the thumb proximal phalanx base ulnar side avulsion fracture.
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  • 文章类型: Journal Article
    目的:拇指掌指节骨(MCP)关节背侧脱位时,MCP关节的位置发生明显变化。然而,芝麻骨位置在诊断关节脱位中的意义尚不清楚。本研究旨在探讨正常和背侧脱位关节中掌指骨与拇指掌指关节的位置关系。
    方法:在2018年1月至2023年8月之间,我们从60名门诊患者中收集了60张等距平片,并在天津医院回顾了28例拇指背侧MCP关节脱位急诊患者的56张等距平片,然后测量了手部X射线图像。其纵轴上的芝麻骨长度定义为DP,种骨远端边缘和拇指MCP关节之间的距离定义为DJ,DJ和DP的比值为R。采用独立样本t检验和配对样本t检验来分析数据组之间的差异。
    结果:60张等距图像来自30名男性和30名女性门诊患者,他们手中的骨骼结构正常,28例急诊患者的56张非等距图像包括术前和术后材料。在门诊病人中,在男性和女性中,芝麻骨和拇指MCP关节间隙(DJ)的远端边缘之间的实际距离为2.09mm和1.40mm,分别。籽粒(DP)的真实平均长度在男性中为4.46毫米,在女性中为4.22毫米。男性和女性的R(DJ和DP之比)的平均值分别为0.49和0.34。DJ(p<0.01)和R(p=0.01)存在性别相关的统计学差异,但DP无统计学差异(p>0.05)。对于28名急诊患者,关节复位前R的平均值为-0.47,关节复位后R的平均值为0.58,两者有统计学差异(p<0.01)。
    结论:关节脱位和关节复位时,芝麻骨和拇指MCP关节的相对位置存在显着差异。超过拇指MCP关节的芝麻骨远端边缘可能是诊断关节背侧脱位的证据。拇指MCP关节下方的芝麻骨远端边缘可能是关节复位的证据。
    OBJECTIVE: The position of sesamoid of thumb metacarpophalangeal (MCP) joint changed clearly when the joint was dislocated dorsally. However, the significance of sesamoid location in diagnosing joint dislocation was unclear. The present study aimed to explore the positional relationship between sesamoid bone and thumb metacarpophalangeal joint in normal and dorsal dislocation joints.
    METHODS: Between January 2018 and August 2023, we collected 60 isometric plain films from sixty outpatients and reviewed 56 anisometric plain films from twenty-eight emergency patients with dorsal dislocation of thumb MCP joint at Tianjin Hospital, then took measurements on the hand X-ray images. The sesamoid length on its longitudinal axis was defined as DP, the distance between the distal edge of sesamoid and thumb MCP joint was defined as DJ, and the ratio of DJ and DP was R. An independent-samples t-test and paired-samples t-test was utilized to analyze difference among data groups.
    RESULTS: The 60 isometric images were from 30 male and 30 female outpatients with normal bone structure in their hands, and the 56 anisometric images of the 28 emergency patients included both preoperative and postoperative materials. Among the outpatients, the actual distance between the distal edge of sesamoid and thumb MCP joint space (DJ) was 2.09 mm and 1.40 mm in males and females, respectively. The authentic average length of sesamoid (DP) was 4.46 mm in males and 4.22 mm in females. The average value of R (the ratio of DJ and DP) in males and females was 0.49 and 0.34, respectively. There were gender-related statistical differences in DJ (p < 0.01) and R (p=0.01), but no statistical difference in DP (p > 0.05). For the 28 emergency patients, the mean value of R was -0.47 before joint reduction and 0.58 after joint reduction, with statistical difference between them (p < 0.01).
    CONCLUSIONS: There was significant difference in the relative position between sesamoid and thumb MCP joint when joint dislocation and joint reduction. The distal edge of sesamoid beyond thumb MCP joint could be an evidence in diagnosing joint dorsal dislocation. The distal edge of sesamoid below thumb MCP joint could be an evidence of joint reduction.
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  • 文章类型: Journal Article
    目的:Ni-Ti记忆合金由于其独特的超弹性,是用于硬组织替代的不寻常材料,良好的生物相容性,高强度,低比重,低磁性,耐磨性,耐腐蚀性和抗疲劳性。本研究旨在评价其力学性能,为该假体的临床应用提供生物力学依据。
    方法:将10例成人掌指关节标本随机分为假体组(n=5,接受掌指关节假体)和对照组(n=5,接受假手术)。首先,用BOSE材料试验机测试轴向压缩强度,以评估其生物力学强度。其次,使用BOSE材料试验机和GOM非接触式光学应变测量系统测试了这些试样的应变变化,以评估应力变化。第三,组间进行疲劳试验.最后,采用ETK5510材料试验机对掌指关节假体的机械磨损进行测试,研究其力学性能。
    结果:在30°和60°屈曲位置,假体组的轴向压缩刚度大于对照组(P<0.05)。两组在轴向压缩刚度和应力变化测试方面差异无统计学意义(P>0.05)。在疲劳磨损试验中,假体组假体的平均质量损失分别为17.2mg和17.619mm3.平均体积磨损率为0.12%。掌骨最大拔出力差异无统计学意义,指骨,假体组和对照组标本之间的聚合物聚乙烯垫。
    结论:Ni-Ti记忆合金掌指关节假体符合无植入物掌指关节的生物力学特征,且疲劳强度能充分满足关节置换后掌指关节活动的需要。
    OBJECTIVE: Ni-Ti memory alloys are unusual materials for hard-tissue replacement because of their unique superelasticity, good biocompatibility, high strength, low specific gravity, low magnetism, wear resistance, corrosion resistance and fatigue resistance. The current study aims to evaluate its mechanical properties and provide biomechanical basis for the clinical application of the prosthesis.
    METHODS: Ten adult metacarpophalangeal joint specimens were randomly divided into a prosthesis group (n = 5, underwent metacarpophalangeal joint prosthesis) and a control group (n = 5, underwent sham operation). Firstly, the axial compression strength was tested with BOSE material testing machine to evaluate its biomechanical strength. Secondly, these specimens were tested for strain changes using BOSE material testing machine and GOM non-contact optical strain measurement system to evaluate the stress changes. Thirdly, fatigue test was performed between groups. Lastly, the mechanical wear of the metacarpophalangeal joint prosthesis was tested with ETK5510 material testing machine to study its mechanical properties.
    RESULTS: Axial compression stiffness in the prosthesis group was greater than that in the control group in terms of 30 ° and 60 ° flexion positions (P < 0.05). There was no statistically significant difference between two groups with regards to axial compression stiffness and stress change test (P > 0.05). In the fatigue wear test, the mean mass loss in the prosthesis group\'s prosthesis was 17.2 mg and 17.619 mm3, respectively. The mean volume wear rate was 0.12%. There was no statistically significant difference in the maximum pull-out force of the metacarpal, phalangeal, and polymer polyethylene pads between the prosthesis group and the control group specimens.
    CONCLUSIONS: Ni-Ti memory alloy metacarpophalangeal joint prosthesis conforms to the biomechanical characteristics of metacarpophalangeal joints without implants, and the fatigue strength can fully meet the needs of metacarpophalangeal joint activities after joint replacement.
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  • 文章类型: Journal Article
    背景:探讨银屑病关节炎(PsA)患者高分辨率外周定量计算机断层扫描(HR-pQCT)的疾病相关参数与关节间隙宽度(JSW)之间的关系。
    方法:本横断面研究招募了接受第二至第四掌指关节(MCPJ2-4)HR-pQCT检查的PsA患者。关节空间度量包括关节空间体积(JSV),意思是,minimum,和最大JSW,JSW不对称,和分配。使用相关性分析和多变量线性回归模型来确定疾病相关变量与JSW之间的关联。
    结果:本分析纳入67例患者[男性37例(55.2%);中位(IQR)年龄:57.0(53.0,63.0);中位病程:21(16,28)年]。多变量线性回归分析表明,男性有较大的JSV(MCPJ2-4),平均值(MCPJ4),和最大JSW(MCPJ3)。较长的病程(MCPJ2-3)和较高的ESR值(MCPJ3)与平均和最大JSW呈负相关,而较高的损伤关节计数与平均和最小JSW(MCPJ2)负相关。使用常规合成的改善疾病的抗风湿药(csDMARDs)与最低JSW(MCPJ3)呈负相关,而使用生物DMARDs(bDMARDs)与最低JSW(MCPJ2)呈正相关。
    结论:较长的病程反映了较高的炎症负担,ESR水平较高,损伤关节计数与平均值负相关,最大值,和最低JSW,而使用bDMARDs抑制炎症似乎限制了JSW的下降。
    To investigate the relationship between disease-related parameters and joint space width (JSW) on high-resolution peripheral quantitative computed tomography (HR-pQCT) in psoriatic arthritis (PsA) patients.
    PsA patients who underwent HR-pQCT examination of the second to fourth metacarpophalangeal joint (MCPJ 2-4) were recruited in this cross-sectional study. The joint space metrics included joint space volume (JSV), mean, minimum, and maximum JSW, JSW asymmetry, and distribution. Correlation analysis and multivariable linear regression models were used to determine the association between disease-related variables and JSW.
    Sixty-seven patients [37 (55.2%) males; median (IQR) age: 57.0 (53.0, 63.0); median disease duration: 21 (16, 28) years] were included in this analysis. Multivariable linear regression analysis demonstrated that males had larger JSV (MCPJ 2-4), mean (MCPJ 4), and maximum JSW (MCPJ 3). Longer disease duration (MCPJ 2-3) and higher ESR values (MCPJ 3) were negatively associated with mean and maximum JSW, while higher damage joint count was negatively associated with mean and minimum JSW (MCPJ 2). Use of conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs) was negatively associated with minimum JSW (MCPJ 3) while use of biologic DMARDs (bDMARDs) was positively associated with minimum JSW (MCPJ 2).
    Higher inflammatory burden as reflected by longer disease duration, higher ESR levels, and damage joint count was negatively associated with mean, maximum, and minimum JSW, while suppression of inflammation using bDMARDs seems to limit the decline in JSW.
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  • 文章类型: English Abstract
    目的:探讨重建掌侧软组织缺损及中远指骨感觉血管修复的手术方法。
    方法:2016年1月至2020年1月,共14例患者,9男5女,年龄从22岁到69岁,并在2至4的中指和远端指掌软组织缺损,使用V-Y形皮瓣在掌指关节处具有指动脉和神经。缺损面积为(2.0~2.5)cm×(1.5~2.0)cm。该程序涉及从掌指关节收获带有指动脉和神经的V-Y形皮瓣。襟翼设计,血管和神经的解剖,并根据标准化方案进行了与指动脉和神经的吻合。,术后3周开始患指功能锻炼。随后进行评估以评估指腹感觉,形状和其他相关参数。根据中华医学会手外科分会制定的上肢功能评价标准,评估手术结果.
    结果:所有14例患者均显示成功的组织移植,,在10例远端指髓缺损中观察到感觉立即恢复。四名中指骨缺损患者在术后2至3个月内经历了逐渐的感觉恢复。13例患者均获随访,平均随访时间(8.8±4.49)个月,在此期间观察到令人满意的结果。指腹的平均两点分辨率为4-6mm,和感官功能评估产生S3或以上的分数。患者表现出逼真的手指形状,正常的皮肤颜色和温度,良好的耐磨性,和耐寒。此外,手指关节功能基本正常。
    结论:掌指关节处带有指动脉和神经的V-Y形皮瓣为修复指中或远端指骨缺损提供了合适的解决方案。这种技术的特点是它的简单,低风险,和有利的结果,包括恢复手指形状,血液供应和感觉。此外,患者满意度较高。
    OBJECTIVE: To explore a surgical method for the reconstruction of volar soft tissue defect and sensory and vascular repair in middle and far phalangeal digits.
    METHODS: From January 2016 to January 2020, a total of 14 patients , 9 males and 5 females, ages ranging from 22 to 69 years old, and with volar soft tissue defects in the middle and distal digits 2 to 4, underwent surgical reconstruction using the V-Y shaped flap with digital artery and nerve at the metacarpophalangeal joint. The defect area was (2.0~2.5) cm×(1.5 ~2.0) cm. The procedure involved the harvest of a V-Y shaped flap with the digital artery and nerve from the metacarpophalangeal joint. Flap design, dissection of blood vessels and nerves, and anastomosis with the digital artery and nerve were performed according to a standardized protocol., Functional exercise of affected finger was initiated 3 weeks postoperatively. Subsequent assessments were conducted to evaluate finger pulp sensation, shape and other relevant parameters. According to the upper extremity functional evaluation standard set up by Hand Surgery Branch of Chinese Medical Association, the surgical outcomes were evaluated.
    RESULTS: All 14 cases demonstrated successful tissue transplantation, , with immediate recovery of sensation observed in 10 cases with distal finger pulp defects. Four patients with middle phalangeal defects experienced gradual sensory recovery within 2 to 3 months postoperatively. Thirteen patients were followed up for a mean duration of (8.8 ± 4.49) months, during which satisfactory outcomes were observed. The average two-point resolution of the finger pulp was 4-6mm, and sensory function evaluation yielded a score of S3 or above. Patients exhibited realistic finger shape, normal skin color and temperature, good wear resistance, and cold resistance. Furthermore, finger joint function was essentially normal.
    CONCLUSIONS: The V-Y shaped flap with digital artery and nerve at the metacarpophalangeal joint offers a suitable solution for repairing the defect of the middle or distal phalangeal finger. This technique is characterized by its simplicity, low risk, and favorable outcomes, including restored finger shape, blood supply and sensation. Moreover, high patient satisfaction was achieved.
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  • 文章类型: Letter
    暂无摘要。
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  • 文章类型: Journal Article
    我们研究了非典型WasselVI型拇指重复的病理解剖结构,为手术治疗提供理论依据。治疗了47例非典型WasselVI型拇指重复的患者。我们发现有些病例的尺骨拇指没有伸肌腱,或者没有屈肌腱,或者两者都没有。所有尺骨掌骨均有不同程度的异常。顶部成形术是目前治疗这种异常的最佳方法。屈指肌腱重建是拇指功能重建的重要因素,保持滑轮和护套的完整是屈肌腱重建的关键步骤。将顶部成形术水平放置在掌骨远端或近端指骨取决于屈肌腱的存在。根据屈肌腱的情况,非典型WasselIV型复制可分为两种类型:缺失型和完整型。证据级别:IV。
    We studied the pathological anatomical structures of atypical Wassel Type VI thumb duplication to provide a theoretical basis for surgical treatment. Forty-seven patients with atypical Wassel Type VI thumb duplication were treated. We found that some of cases had an ulnar thumb without an extensor tendon, or without a flexor tendon, or without both. All the ulnar metacarpal bones were abnormal to variable degrees. On-top-plasty is currently the best procedure for the treatment of this type of anomaly. Flexor tendon reconstruction is an important factor in functional reconstruction of the thumb, and keeping the pulley and sheath intact is a key step in flexor tendon reconstruction. Placing the on-top-plasty level at the distal end of the metacarpal or at the proximal phalanx depends on the presence of the flexor tendon. According to the condition of the flexor tendon, the atypical Wassel Type IV duplication can be divided into two types: the absent type and the intact type.Level of evidence: VI.
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  • 文章类型: Journal Article
    目的:确定患有关节痛的原发性干燥综合征(pSS)患者有患骨关节炎(OA)或关节炎的风险。
    方法:本研究包括2010年3月至2020年12月接受单中心治疗的368例pSS患者。根据是否并发OA或关节炎将患者分为两组。对数据进行了分析,以确定人口统计学特征的差异,症状,和实验室检查。
    结果:OA关节受累主要是膝关节和脊柱部位(包括颈椎和腰椎退变)。诊断关节炎时,主要是外周对称性多关节炎,受影响最大的部位是指间关节和掌指关节。年龄差异显著,疾病持续时间,尿酸(UA),pSS-OA和pSS-nOA患者的总胆固醇(TC)(P<0.050)。Logistic回归分析显示,年龄(OR=1.965;P=0.009)和关节痛(OR=3.382;P<0.001)是OA发病的危险因素。有趣的是,虽然UA的水平,TC,甘油三酯(TG)显示为OA阳性,在四细胞表中计算OR后,无统计学意义.在pSS-关节炎中,EULARSjögren综合征疾病活动指数(ESSDAI)(P=0.011),关节疼痛的频率(P<0.001),和肌肉受累(P=0.037)高于非关节炎组。在仅出现关节痛的pSS患者中,关节炎患者有较高的ESSDAI和系统受累,但UA和TG水平低于OA组(P<0.050)。
    结论:在有关节痛的pSS患者中,OA占大多数。具有高龄和更明显的代谢特征的pSS患者,如血脂和尿酸升高,是OA风险人群的关键因素。然而,关节炎患者口干眼的发生率较高,更高的疾病活动,抗体阳性,更多的器官损伤。在未来,在诊断pSS患者的关节表现时,可能需要更加谨慎,以便做出适当的治疗。
    OBJECTIVE: To identify primary Sjögren\'s syndrome (pSS) patients with arthralgia at risk for osteoarthritis (OA) or arthritis.
    METHODS: This study included 368 pSS patients admitted to a mono-centric from March 2010 to December 2020. Patients were divided into groups according to whether complicated with OA or arthritis. Data were analyzed to determine the differences in demographical characteristics, symptoms, and laboratory examination.
    RESULTS: The involvement of the OA joints was predominately knee and spine sites (including cervical and lumbar spine degeneration). When diagnosing arthritis, it was mainly peripheral symmetric polyarthritis, the most affected sites were the interphalangeal and metacarpophalangeal joints. There were significant differences in age, disease duration, uric acid (UA), and total cholesterol (TC) between pSS-OA and pSS-nOA patients (P < 0.050). Logistic regression analysis showed that age (OR = 1.965; P = 0.009) and joint pain (OR = 3.382; P < 0.001) were dangerous factors associated with OA. Interestingly, although the level of UA, TC, and triglycerides (TG) was shown to be positive with OA, there was no statistical significance after the OR was computed in the four-cell table. In pSS-arthritis, EULAR Sjögren\'s syndrome disease activity index (ESSDAI) (P = 0.011), the frequency of joint pain (P < 0.001), and muscular involvement (P = 0.037) were higher than non-arthritis group. In pSS patients only presenting with joint pain, arthritis patients had higher ESSDAI and system involvements, but lower UA and TG levels compared with OA group (P < 0.050).
    CONCLUSIONS: In pSS patients with arthralgia, OA accounted for the majority. pSS patients with advanced age and more pronounced metabolic characteristics, such as elevated blood lipids and uric acid, was a key factor in groups at risk for OA. However, arthritis patients had higher rates of dry mouth and eye, higher disease activity, antibodies positive, and more organs damage. In the future, it may be necessary to be more cautious in the diagnosis of joint manifestations in pSS patients in order to make the appropriate treatments.
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  • 文章类型: Journal Article
    背景:由于最复杂的骨骼和软组织异常,难以治疗放射状多指IV-D型畸形。切除和重建两个拇指之一是治疗的一种选择。
    目的:本研究提出了一种新的切口切除和重建IV-D型放射状多指的方法,并使用鹿特丹评估系统在大样本中综合评价临床疗效。
    方法:2010-2019年对206例IV-D型拇指重复行切除重建手术治疗。围绕the拇指设计了两个相等的三角形皮瓣切口。切除桡骨拇指,重建尺骨拇指,肌腱,韧带和拐卖者Pollicisbrevis.使用鹿特丹评估系统评估临床结果。
    结果:平均随访期为2.2年(标准差1.5)。手术时患者的平均年龄为9个月(SD1.8)。活动IP和MP关节屈伸的平均范围为110°和26°。IP和MP关节不稳定性的平均角度为3°和11°,相对而言。手掌外展的角度为58°。平均外观域评分为8.9。父母满意度平均评分为2.5,患者报告的疼痛平均评分为2.1。所有患者的平均功能域评分为6.6。平均外观域评分为8.9。患者报告的平均领域评分为4.5。鹿特丹结果的平均得分为20.0分,相当于满分的67%。2岁以上患者术后评分明显低于2岁以下患者。
    结论:两个等三角形皮瓣切口的切除和重建方法是放射状多指IV-D型的推荐治疗方法。
    方法:IV.
    BACKGROUND: Radial Polydactyly Type IV-D deformity is difficult to treat because of the most complex bone and soft tissue anomalies. Resection and reconstruction for one of the two thumbs was an option for treatment.
    OBJECTIVE: The study was to present our method of resection and reconstruction with a new incision for radial polydactyly Type IV-D and evaluate the clinical efficacy comprehensively using Rotterdam assessment system in a large sample.
    METHODS: 206 cases of type IV-D thumb duplication underwent resection and reconstruction surgical treatment between 2010 and 2019. Two equal triangle flap incisions were designed around the radial thumb. The radial thumb was resected and the ulnar thumb was reconstructed in aspects of bone, tendons, ligaments and abductor pollicis brevis. The clinical results were evaluated using Rotterdam assessment system.
    RESULTS: The mean follow-up period was 2.2 years (SD 1.5). The mean age of the patients was 9 months (SD 1.8) at the time of operation. The mean ranges of active IP and MP joint flexion and extension were 110° and 26°. The mean angulations for IP and MP joint instabilities were 3° and 11°, relatively. Angulation for palmar abduction was 58°. The mean appearance domain score was 8.9. The average parental satisfaction score was 2.5 and the average patient-reported pain score was 2.1. The mean functional domain score for all patients was 6.6. The average appearance domain score was 8.9. The mean patient-reported domain score was 4.5. The mean Rotterdam outcome score was 20.0, equivalent to 67% of the full score. The postoperative score of patients over two years old was significantly lower than that of patients under two years old.
    CONCLUSIONS: Resection and reconstruction method with two equal triangle flap incisions was a recommended treatment for radial polydactyly Type IV-D.
    METHODS: IV.
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  • 文章类型: Journal Article
    目的:通过深度学习(DL)方法评估超声图像中类风湿关节炎(RA)掌指关节状况的自动分类是否可行,为了提供更客观的,自动化,以及临床上RA诊断的快速方法。
    方法:使用基于DenseNet的DL模型,训练和测试都在TensorFlow1.13.1中使用KerasDL库实现。曲线下面积(AUC),准确度,灵敏度,报告了95%CI的特异性值。统计分析是通过使用Python3.7中的scikit-learn库进行的。
    结果:共采集了208例RA患者的1337张超声图像,在OESS等级L0、L1、L2和L3中,图像的数量分别为313、657、178和189。在分类方案1中,SP-否与SP-是,三个感兴趣区域大小为192×448的实验(第1组),96×224(第2组),和96×224与预分割的带注释的SP面积(组3)作为输入堆叠实现0.863的AUC(95%CI:0.809,0.917),0.861(95%CI:0.805,0.916),和0.886(95%CI:0.836,0.936),分别。在分类方案2中,健康与患病,第1组,第2组和第3组的实验达到0.848的AUC(95%CI:0.799,0.896),0.864(95%CI:0.819,0.909),和0.916(95%CI:0.883,0.952),分别。
    结论:我们将DenseNet模型与超声图像相结合,用于RA病情评估。还证明了使用DL创建自动RA状况分类系统的可行性。所提出的方法可以替代RA患者的初始筛查。
    OBJECTIVE: To evaluate if an automatic classification of rheumatoid arthritis (RA) metacarpophalangeal joint conditions in ultrasound images is feasible by deep learning (DL) method, to provide a more objective, automated, and fast way of RA diagnosis in clinical setting.
    METHODS: DenseNet-based DL model was used and both training and testing are implemented in TensorFlow 1.13.1 with Keras DL libraries. The area under curve (AUC), accuracy, sensitivity, and specificity values with 95% CIs were reported. The statistical analysis was performed by using scikit-learn libraries in Python 3.7.
    RESULTS: A total of 1337 RA ultrasound images were acquired from 208 patients, the number of images is 313, 657, 178, and 189 in OESS Grade L0, L1, L2, and L3, respectively. In Classification Scenario 1 SP-no versus SP-yes, three experiments with region of interest of size 192 × 448 (Group 1), 96 × 224 (Group 2), and 96 × 224 stacked with pre-segmented annotated mask of SP area (Group 3) as input achieve an AUC of 0.863 (95% CI: 0.809, 0.917), 0.861 (95% CI: 0.805, 0.916), and 0.886 (95% CI: 0.836, 0.936), respectively. In Classification Scenario 2 Healthy versus Diseased, experiments in Group 1, Group 2 and Group 3 achieve an AUC of 0.848 (95% CI: 0.799, 0.896), 0.864 (95% CI: 0.819, 0.909), and 0.916 (95% CI: 0.883, 0.952), respectively.
    CONCLUSIONS: We combined DenseNet model with ultrasound images for RA condition assessment. The feasibility of using DL to create an automatic RA condition classification system was also demonstrated. The proposed method can be an alternative to the initial screening of RA patients.
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