■这项研究的目的是检查前巨眼（AM）的生物识别眼部表现和结构眼部特征。
■纳入复旦大学附属耳鼻喉科医院15例AM患者（30只眼）。年龄匹配的对照组由30名参与者（30只眼）组成，他们对一只正常眼睛进行了PentacamHR和IOLMaster700测量。人口统计数据，生物识别表现，和基因型进行了仔细比较。
■共纳入15例AM患者和30例对照患者。年龄没有差异（37.27±19.1vs.31.43±19.69岁，两组之间的P=0.249）。与对照组相比，AM眼的特征是过早白内障（11/30，36.67％）和软骨无力伴晶状体半脱位（22/30，73.33％）。值得注意的是,30只眼中有20只眼（66.67％）出现明显的后虹膜弯曲，在超声生物显微镜（UBM）上，30只眼睛中有16只（53.33％）显示睫状环增大。AM眼的平均角膜曲率较低（42.01±2.06D与43.14±1.38D,P=0.023)。AM组和对照组之间的角膜厚度和中央内皮细胞计数没有显着差异。AM患者的PentacamHR和IOLMaster700在前房和白色到白色（WTW）方面存在显着差异（P<0.05）。差异为0.53±0.48mm和0.36±0.14mm,分别(P<0.001)。
■这项队列研究的结果总结了中国队列中的生物特征和结构性眼部表现。后虹膜弯曲（66.67％）和晶状体半脱位（73.33％）是AM患者最大角膜解剖异常和深前房的最特征性发现，尽管AM的角膜生物特征表现包括较平坦的角膜和较低的总角膜散光。掌握AM眼部表现的知识对于术前诊断和术前准备具有重要意义,避免术中术后并发症的发生。PentacamHR和IOLMaster700之间的前房和WTW值存在显着差异。因此，我们建议在确定AM诊断前应仔细考虑各种检查.
UNASSIGNED: The aim of this study was to examine the biometric ocular manifestations and structural ocular features of anterior megalophthalmos (AM).
UNASSIGNED: Fifteen patients with AM (30 eyes) from the Eye & ENT Hospital of Fudan University were included. The age-matched control group consisted of 30 participants (30 eyes) who underwent Pentacam HR and IOLMaster 700 measurements for one normal eye. Data on demographics, biometric manifestations, and genotypes were carefully compared.
UNASSIGNED: A total of 15 patients with AM and 30 control patients were enrolled. There were no differences in age (37.27 ± 19.1 vs. 31.43 ± 19.69 years, P = 0.249) between these two groups. AM eyes were characterized by premature cataracts (11/30, 36.67%) and zonular weakness with lens subluxation (22/30, 73.33%) compared with the control group. Notably, 20 of the 30 AM eyes (66.67%) had significant posterior iris bowing, and 16 of the 30 AM eyes (53.33%) showed an enlarged ciliary ring on ultrasound biomicroscopy (UBM). Mean corneal curvature was lower in the AM eyes (42.01 ± 2.06 D vs. 43.14 ± 1.38 D, P = 0.023). There was no significant difference in corneal pachymetry and central endothelial cell count between the AM and control groups. Significant differences were found in terms of the anterior chamber and white-to-white (WTW) among the Pentacam HR and IOLMaster 700 in patients with AM (P < 0.05). The difference was 0.53 ± 0.48 mm and 0.36 ± 0.14 mm, respectively (P < 0.001).
UNASSIGNED: The results of this cohort study conclude the biometric and structural ocular manifestations in Chinese cohorts. Posterior iris bowing (66.67%) and lens subluxation (73.33%) are the most characteristic findings in patients with AM with anatomical abnormalities of
megalocornea and a deep anterior chamber, although corneal biometric manifestations of AM included flatter cornea and lower total corneal astigmatism. The knowledge of ocular manifestations of AM is important for diagnosis and preparation for the operation in advance to avoid intraoperative and postoperative complications. Significant differences were found in the anterior chamber and WTW values between the Pentacam HR and IOLMaster 700. Thus, we suggest that various examinations should be carefully considered before determining an AM diagnosis.
PDF(Pubmed)