头颈部腺样囊性癌(ACC)的主要治疗方法是手术切除,切缘阴性。这项研究的目的是确定与头颈部ACC生存结果相关的边缘状态。
我们对国际数据进行了单变量和多变量分析。
分析了507例头颈部ACC患者的数据;在253例患者(50%)中检测到定义为≥5mm的阴性边缘。在多变量分析中,阳性边缘状态的风险比(HRs)为2.68(95%置信区间[CI],1.2-6.2;p=.04)和2.63(95%CI,1.1-6.3;p=.03)的总生存期(OS)和疾病特异性生存期(DSS),分别。接近利润率对结果没有显著影响,OS和DSS的HR为1.1(95%CI,0.4-3.0;p=.12)和1.07(95%CI,0.3-3.4;p=.23),分别,相对于负利润率。
在头颈部ACC,正利润率与最坏的结果有关。负或接近的利润率与改善的结果相关,与肿瘤的距离无关。©2017Wiley期刊,公司头颈39:1008-1014,2017。
The mainstay of treatment in adenoid cystic carcinoma (ACC) of the head and neck is surgical resection with negative
margins. The purpose of this study was to define the margin status that associates with survival outcomes of ACC of the head and neck.
We conducted univariate and multivariate analyses of international data.
Data of 507 patients with ACC of the head and neck were analyzed; negative
margins defined as ≥5 mm were detected in 253 patients (50%). On multivariate analysis, the hazard ratios (HRs) of positive margin status were 2.68 (95% confidence interval [CI], 1.2-6.2; p = .04) and 2.63 (95% CI, 1.1-6.3; p = .03) for overall survival (OS) and disease-specific survival (DSS), respectively. Close
margins had no significant impact on outcome, with HRs of 1.1 (95% CI, 0.4-3.0; p = .12) and 1.07 (95% CI, 0.3-3.4; p = .23) for OS and DSS, respectively, relative with negative
margins.
In head and neck ACC, positive
margins are associated with the worst outcome. Negative or close margins are associated with improved outcome, regardless of the distance from the tumor. © 2017 Wiley Periodicals, Inc. Head Neck 39: 1008-1014, 2017.