■为了研究血浆脱脂体外脂蛋白过滤器（DELP）系统的安全性和有效性，一种新的低密度脂蛋白胆固醇（LDL-C）吸附系统，急性缺血性卒中（AIS）患者。
■在本研究中，2019年3月至2021年2月,共纳入180例AIS患者.分为DELP组(n1=90)和对照组(n2=90)。建立并评估DELP治疗的治疗方案和血管通路。对于DELP组，收集并分析单采前后的临床数据和实验室结果，包括血浆脂质和安全性参数。对于所有参与者，评估并记录神经系统评分.
■对于DELP组，90例患者包括70例男性和20例女性。平均LDL-C从3.15±0.80mmol/L显著降低至2.18±0.63mmol/L(30.79%,p<0.001)在单次DELP治疗期间，从3.42±0.87mmol/L降至1.87±0.48mmol/L（45.32%，两次DELP处理后p<0.001)。在整个DELP治疗期间,除了血细胞比容和总蛋白,没有观察到血液学安全性参数和血压水平的临床相关变化。在卒中后第14天和第90天，DELP组在美国国立卫生研究院卒中量表（NIHSS）评分中显示出相对于对照组的改善。此外，在卒中后第90天,DELP组的mRS0与1的比值显著较高.
■新的LDL-C吸附系统，DELP系统,鉴于其安全性，可能为AIS患者的强化降脂治疗提供新的选择，功效,和操作的可行性。
UNASSIGNED: To investigate the safety and efficacy of the delipid extracorporeal lipoprotein filter from plasma (DELP) system, a new low-density lipoprotein cholesterol (LDL-C) adsorption system, in acute ischemic stroke (AIS) patients.
UNASSIGNED: In the present study, a total of 180 AIS patients were enrolled during March 2019 to February 2021. They were divided into DELP group (n1 = 90) and the control group (n2 = 90). The treatment protocol and vascular access of DELP treatment was established and evaluated. For the DELP group, clinical data and laboratory results including plasma lipid and safety parameters before and after the apheresis were collected and analyzed. For all participants, neurological scores were assessed and recorded.
UNASSIGNED: For the DELP group, 90 patients including 70 males and 20 females were included. The mean LDL-C was significantly decreased from 3.15 ± 0.80 mmol/L to 2.18 ± 0.63 mmol/L (30.79%, p < 0.001) during a single DELP treatment, and decreased from 3.42 ± 0.87 mmol/L to 1.87 ± 0.48 mmol/L (45.32%, p < 0.001) after two DELP treatments. No clinically relevant changes were observed in hematologic safety parameters and blood pressure levels except for hematocrit and total protein throughout the whole period of DELP treatment. The DELP group showed improvement relative to the control group in National Institute of Health stroke scale scores (NIHSS) on the 14th and 90th day after stroke. Moreover, the DELP group had a significantly higher ratio of mRS 0 to 1 on the 90th day after stroke.
UNASSIGNED: The new LDL-C adsorption system, the DELP system, may provide a new option for intensive lipid lowering therapy in AIS patients in view of its safety, efficacy, and operation feasibility.
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