UNASSIGNED:本研究的目的是评估产妇牙周疾病(PD)与三种主要新生儿不良结局之间的关系,即,早产(PTB),低出生体重(LBW),小于胎龄(SGA)。
未经批准:OvidMedline,WebofScience,Embase,和Cochrane图书馆在2020年12月6日之前进行了搜索,以进行有关PD与PTB风险之间关联的相关观察性研究,LBW,SGA。合格标准包括观察性研究,该研究比较了PD女性和牙周健康对照之间PTB和/或LBW和/或SGA的患病率。排除标准包括不完整的数据,动物研究,混合了各种妊娠结局,如“早产低出生体重”以及中文和英文以外的语言。数据由两位作者独立提取和分析。使用Stata统计软件进行荟萃分析,第12版(StataCorpLP,学院站,TX,美国)。赔率比(OR),置信区间(CI),并计算了异质性(I2)。
未经评估:14项病例对照研究和10项前瞻性队列研究,涉及15278名参与者,已确定。基于固定效应的荟萃分析,在随机效应荟萃分析中,PTB与PD显著相关(OR=1.57,95%CI:1.39-1.77,P<0.00001),LBW也与PD显著相关(OR=2.43,95%CI:1.75-3.37,P<0.00001)。然而,随机效应荟萃分析显示PD与SGA之间无相关性(OR=1.62,95%CI:0.86~3.07,P=0.136)。
UNASSIGNED:我们的研究结果表明,患有PD的孕妇患PTB和LBW的风险明显更高。然而,大的前瞻性,仍然需要具有标准化的PD诊断标准和对混杂因素的充分控制的双盲队列研究来确认PD与新生儿不良结局之间的关系.
UNASSIGNED: The aim of this study was to evaluate the association between maternal periodontal disease (PD) and three main adverse neonatal outcomes, namely, preterm birth (PTB), low birth weight (LBW), and small for gestational age (SGA).
UNASSIGNED: The Ovid Medline, Web of Science, Embase, and Cochrane Library were searched up to 6 December 2020 for relevant observational studies on an association between PD and risk of PTB, LBW, and SGA. Eligibility criteria included observational studies which compared the prevalence of PTB and/or LBW and/or SGA between PD women and periodontal health controls. The exclusion criteria included incomplete data, animal research, and mixing up various pregnancy outcomes, such as \"preterm low birth weight\" and languages other than Chinese and English. Data were extracted and analyzed independently by two authors. The meta-analysis was performed using Stata Statistical Software, Release 12 (StataCorp LP, College Station, TX, USA). Odds ratio (OR), confidence intervals (CIs), and heterogeneity (I 2) were computed.
UNASSIGNED: Fourteen case-control studies and 10 prospective cohort studies, involving 15,278 participants, were identified. Based on fixed effect meta-analysis, PTB showed a significant association with PD (OR = 1.57, 95% CI: 1.39-1.77, P < 0.00001) and LBW also showed a significant association with PD (OR = 2.43, 95% CI: 1.75-3.37, P < 0.00001) in a random effect meta-analysis. However, a random effect meta-analysis showed no relationship between PD and SGA (OR = 1.62, 95% CI: 0.86-3.07, P = 0.136).
UNASSIGNED: Our findings indicate that pregnant women with PD have a significantly higher risk of PTB and LBW. However, large prospective, blinded cohort studies with standardized diagnostic criteria of PD and adequate control of confounding factors are still required to confirm the relationship between PD and adverse neonatal outcomes.