背景:结膜结膜炎(LC)是一种罕见的结膜炎性病变,病因不明。临床诊断易与结膜淋巴瘤或其他疾病混淆,病变很难治疗。
方法:我们介绍了一名41岁女性患者,表现为双侧结膜肿块超过6个月。患者无眼外伤史,肿瘤家族史和药物过敏史。结合患者的临床和病理特征,我们认为这是一例IgG4+LC。完全手术切除联合局部糖皮质激素治疗可能是有效的。
结论:这是一例非常罕见的免疫球蛋白G4阳性LC病例报告,文献中只有一例已发表。LC的典型表现是坚硬的外观,富含纤维蛋白,木质假膜性病变。病理组织中有大量淋巴细胞和浆细胞浸润。LC的炎症可能导致免疫异常,导致IgG4增加。
BACKGROUND: Ligneous conjunctivitis (LC) is a rare inflammatory lesion of the conjunctiva with an unknown etiology. It is easily confused with conjunctiva lymphoma or other diseases in clinical diagnosis, and the lesion is very difficult to treat.
METHODS: We presented a 41-year-old female patient presented with bilateral conjunctival masses for more than six months. The patient had no contributory history of ocular trauma, family history of tumor and drug allergy. Taking the patient\'s clinical and pathological features together, we considered this was a case of IgG4 + LC. Completely surgical resection combined with local glucocorticoid treatment might be effective.
CONCLUSIONS: This is a very rare case report of immunoglobulin G4 positive LC with only one published case in literature. The typical manifestations of LC are with the appearance of a hard, fibrin-rich, woody pseudomembranous lesion. A large number of lymphocyte and plasma cell are infiltrated in the pathological tissue. Inflammation of LC may cause immune abnormalities, resulting in IgG4 increasing.