背景:阻塞性睡眠呼吸暂停低通气综合征(OSAHS)是一种常见的呼吸系统疾病,具有潜在的致死性。目前,常用的治疗方法是持续气道正压通气,但是随着病程的延长,单一通气对氧化应激水平的改善效果不佳。硫辛酸是临床上常用的抗氧化剂。在本文中,探讨硫辛酸联合持续气道正压通气对患者是否有较好的治疗效果。
目的:探讨硫辛酸联合持续气道正压通气治疗OSAHS的临床疗效。
方法:前瞻性收集2021年3月至2022年9月在我院治愈的82例OSAHS患者作为研究对象。根据不同的治疗方法,将患者分为对照组(43例)和观察组(39例)。对照组采用持续气道正压通气(CPAP),观察组在对照组的基础上加用硫辛酸治疗。通过呼吸暂停低通气指数(AHI)测量治疗效果,氧饱和度(SpO2),平均氧饱和度(MSpO2),血清丙二醛(MDA),超氧化物歧化酶(SOD),缺氧诱导因子-1α(HIF-1α)水平,外周血γ-氨基丁酸,褪黑激素水平。
结果:观察组临床疗效优于对照组(P<0.05)。治疗后,AHI,观察组MDA、HIF-1α水平较低,SpO2、MSpO2和SOD,γ-氨基丁酸,褪黑素水平高于对照组(P<0.05)。γ-氨基丁酸和褪黑素水平与症状严重程度呈负相关,ESS,AIS评分(P<0.05)。
结论:硫辛酸联合CPAP治疗OSAHS的临床效果较好。对外周血中γ-氨基丁酸和褪黑素水平有积极作用。在原方法中加入硫辛酸进行处理,治疗效果大大提高。
BACKGROUND: Obstructive sleep apnea-hypopnea syndrome (OSAHS) is a common respiratory disease with potential lethality. At present, the commonly used treatment method is continuous positive airway pressure ventilation, but with the prolongation of the course of the disease, the effect of single ventilation on the improvement of oxidative stress levels is not good. Lipoic acid is a commonly used antioxidant in clinics. In this paper, lipoic acid combined with continuous positive airway pressure ventilation is used to explore whether it has a better therapeutic effect on patients.
OBJECTIVE: To probe into the clinical efficacy of lipoic acid combined with continuous positive airway pressure ventilation in the therapy of OSAHS.
METHODS: 82 patients with OSAHS who were cured in our hospital from March 2021 to September 2022 were prospectively collected as subjects. Based on different treatment methods, patients were grouped into a control group (43 cases) and an observation group (39 cases). The control group was treated with continuous positive airway pressure (CPAP), and the observation group was treated with lipoic acid based on control group. The therapeutic effects were measured by apnea hypopnea index (AHI), oxygen saturation (SpO2), mean oxygen saturation (MSpO2), serum malondialdehyde (MDA), superoxide dismutase (SOD), hypoxia inducible factor-1α (HIF-1α) levels, peripheral blood γ-aminobutyric acid, melatonin levels.
RESULTS: The clinical effectiveness of the observation group was better (P < 0.05). After treatment, AHI, the levels of MDA and HIF-1α in the observation group were lower and SpO2, MSpO2 and the level of SOD, γ- aminobutyric acid, and melatonin were higher than those in the control group (P < 0.05). The levels of γ- aminobutyric acid and melatonin were negatively correlated with the severity of symptoms, ESS, and AIS scores (P < 0.05).
CONCLUSIONS: The clinical effect of lipoic acid combined with CPAP in the treatment of OSAHS is better, and it has a positive effect on the levels of γ-aminobutyric acid and melatonin in peripheral blood. Lipoic acid was added to the original method for treatment, and the therapeutic effect was greatly improved.