UNASSIGNED:本研究旨在研究使用二尖瓣反流的连续波多普勒频谱估计左心房压力(LAP)的准确性。
UNASSIGNED:通过一次性活检钳和注射三聚氰胺甲醛树脂微球悬浮液,建立了左心房高血压伴二尖瓣反流的狗模型。通过注射艾司洛尔或多巴酚丁胺建立了40个具有不同血流动力学状态的左心房高血压模型,其中二尖瓣反流频谱清晰,反流速度超过3.5m/s。记录并分析二尖瓣返流的连续波多普勒频谱以估计左心房压力(LAPECHO)。平均左心房压(LAPC-MEAN),等容量舒张左心房压(LAPC-IVRT),最大左心房压(LAPC-MAX),在同一心动周期中使用导管法测量最低左心房压(LAPC-MIN)。
未经评估:LAPECHO(平均值±标准偏差;11.77±4.36mmHg)与LAPC-MEAN(11.51±4.77mmHg;r=0.887,P=0.000)相关,但差异无统计学意义(P=0.459)。LAPECHO与LAPC-IVRT相关(12.16±4.72mmHg;r=0.883,P=0.000),但差异无统计学意义(P=0.271)。LAPC-MEAN与LAPC-IVRT之间存在相关性(r=0.987,P=0.000),差异有统计学意义(P=0.000)。
UNASSIGNED:这项研究表明,LAP的超声评估与使用金标准导管方法测量的LAP具有良好的相关性,是一个简单的,方便,定量估计LAP的非侵入性方法。这种方法很有前途,但是还需要进行进一步的大规模动物实验和临床研究。
UNASSIGNED: This study sought to investigate the accuracy of estimating left atrial pressure (LAP) using the continuous wave Doppler spectrum of mitral regurgitation.
UNASSIGNED: Dog models of left atrial hypertension with mitral regurgitation were established with disposable biopsy forceps and the injection of melamine formaldehyde resin microsphere suspension. A total of 40 models of left atrial hypertension with different hemodynamic statuses were established by injecting either esmolol or dobutamine in which the spectrums of mitral regurgitation were clear and the regurgitation velocity exceeded 3.5 m/s. The continuous wave Doppler spectrums of mitral regurgitation were recorded and analyzed to estimate left atrial pressure (LAPECHO). The mean left atrial pressure (
LAPC-MEAN), the isovolumic diastolic left atrial pressure (
LAPC-IVRT), the maximum left atrial pressure (
LAPC-MAX), and the minimum left atrial pressure (
LAPC-MIN) were also measured using the catheter method in the same cardiac cycle.
UNASSIGNED: The LAPECHO (mean ± standard deviation; 11.77±4.36 mmHg) was correlated with the
LAPC-MEAN (11.51±4.77 mmHg; r=0.887, P=0.000), but the difference was not statistically significant (P=0.459). The LAPECHO was correlated with the
LAPC-IVRT (12.16±4.72 mmHg; r=0.883, P=0.000), but the difference was not statistically significant (P=0.271). There was a correlation between the
LAPC- MEAN and the
LAPC-IVRT (r=0.987, P=0.000), and the difference was statistically significant (P=0.000).
UNASSIGNED: This study suggests that the ultrasound evaluation of LAP correlates well with LAP measured using the gold standard catheter method, and is a simple, convenient, non-invasive method to quantitatively estimate LAP. This method is promising, but further large-scale animal experiments and clinical studies need to be conducted.