KNOX(KNOTTED1-likeHOMEOBOX)属于一类重要的同源异型盒基因,编码与靶基因特定元件结合的同源结构域蛋白,广泛参与植物发育。遗传学和分子生物学研究的进步产生了关于模型和非模型植物中KNOX基因的大量信息,它们在不同发展背景下的功能逐渐清晰。在这次审查中,我们总结了KNOX基因在植物中的已知和假定功能,专注于园艺植物和农作物。分类和结构特征,表达特征和调控,相互作用的蛋白质因素,功能,系统描述了KNOX基因的作用机制。Further,讨论了当前的研究差距和前景。这些综合数据可为通过KNOX基因调控定向改良农艺性状提供参考。
KNOX (KNOTTED1-like HOMEOBOX) belongs to a class of important homeobox genes, which encode the homeodomain proteins binding to the specific element of target genes, and widely participate in plant development. Advancements in genetics and molecular biology research generate a large amount of information about KNOX genes in model and non-model plants, and their functions in different developmental backgrounds are gradually becoming clear. In this review, we summarize the known and presumed functions of the KNOX gene in plants, focusing on horticultural plants and crops. The classification and structural characteristics, expression characteristics and regulation, interacting protein factors, functions, and mechanisms of KNOX genes are systematically described. Further, the current research gaps and perspectives were discussed. These comprehensive data can provide a reference for the directional improvement of agronomic traits through KNOX gene regulation.