肾小球旁细胞瘤(JGCTs)或肾癌是罕见的肾脏肿瘤,可导致继发性高血压。非特异性临床表现给诊断带来挑战。本研究旨在总结其临床特点,实验室发现,和JGCT的治疗。PubMed,EMBASE数据库,并利用人工搜索找到所有病例,并确定了158份包含261名患者的报告.关于患者人口统计学的数据,临床特征,诊断方法,收集和分析治疗方案。JGCT主要发生在女性患者中(男女比例,2.1:1).患者的中位年龄为25岁(IQR:18-34岁)。高血压(97.24%)是主要表现。低钾血症在78.71%(159/202)的受试者中报告,正常血钾占20.79%(42/202)。在评估血浆肾素活性(PRA)水平的情况下,中位数PRA是正常上限的7.89倍(IQR:3.58-14.41),3.82%(5/131)的病例在正常范围内。97.8%(175/179)的计算机断层扫描(CT)检测到肿瘤,94.7%(72/76)磁共振成像(MRI),和81.5%(110/135)超声,分别。对于250/261例接受外科手术的患者,89.14%(197/221),94.94%(150/158),100%(131/131)的患者血压恢复正常,PRA,和血清钾,分别。JGCT通常与高血压有关,低钾血症,和高肾素血症,而血压正常的患者,正常血钾,药物洗脱持续2周后,应系统地追踪PRA。CT和MRI是较敏感的影像诊断方法。多数患者术后血压及生化指标恢复正常。
Juxtaglomerular cell tumors (JGCTs) or reninoma are rare kidney tumors leading to secondary hypertension, and the non-specific clinical manifestations bring about challenges to the diagnosis. This study is to summarize the clinical features, laboratory findings, and treatment of JGCTs. The PubMed, EMBASE database, and manual search were utilized to find all cases, and 158 reports containing 261 patients were identified. Data on patients\' demographics, clinical features, diagnostic methods, and treatment options were collected and analyzed. JGCTs occurred predominantly in female patients (female to male ratio, 2.1:1). The median age of patients was 25 years (IQR:18-34 years). Hypertension (97.24%) was the cardinal manifestation. Hypokalemia was reported in 78.71% (159/202) of subjects, and normal serum potassium accounted for 20.79% (42/202). In cases with assessed plasma renin activity (PRA) levels, the median PRA was 7.89 times the upper limit of normal (IQR:3.58-14.41), and 3.82% (5/131) of cases in the normal range. Tumors were detected in 97.8% (175/179) computed tomography (CT), 94.7% (72/76) magnetic resonance imaging (MRI), and 81.5% (110/135) ultrasound, respectively. For 250/261 patients undergoing surgical procedures, 89.14% (197/221), 94.94% (150/158), and 100% (131/131) of patients were restored to normal blood pressure, PRA, and serum potassium, respectively. JGCTs are commonly associated with hypertension, hypokalemia, and hyperreninemia, whereas patients with normotension, normokalemia, and PRA should be systematically pursued after drug-elution lasting for 2 weeks. CT and MRI are more sensitive imaging diagnostic methods. The blood pressure and biochemical parameters of most patients returned to normal after surgery.