背景:心房颤动是一种已提出的来源不明的栓塞性卒中(ESUS)的机制。左心房(LA)应变可以在结构变化之前识别早期心房心脏病。我们的目的是研究LA菌株之间的关联,ESUS,和ESUS中的心房颤动(AF)检测。
方法:研究人群包括2016年1月至2017年6月在罗德岛医院卒中中心就诊并接受经胸超声心动图检查的ESUS和非心源性(NCE)卒中患者。斑点追踪超声心动图(STE)用于测量LA应变的三个阶段(储层,导管,和收缩)。进行二元逻辑回归分析以确定LA菌株与卒中亚型之间的关联(ESUS与NCE)以及ESUS患者房颤的随访检测。
结果:我们确定了656名患者,307与ESUS和349与NCE。在二元逻辑回归中,洛杉矶水库的最低三分位数(调整后OR1.944,95%CI1.266-2.986,p=0.002),收缩(aOR1.568,95%CI1.035-2.374,p=0.034),与NCE卒中相比,导管菌株(aOR2.288,95%CI1.448-3.613,p=.001)更可能与ESUS显着相关。在所有ESUS患者中,LA储层应变的最低三元率(OR2.534,95%CI1.029-6.236,p=0.043),收缩应变(OR2.828,95%CI1.158-6.903,p=0.022),导管应变(OR2.614,95%CI1.003-6.815,p=.049)与随后的房颤检测显著相关。
结论:在ESUS患者中,LA劳损降低与ESUS发生和AF检测相关。因此,ESUS患者LA菌株的量化可以改善风险分层并指导二级预防策略.
BACKGROUND: Atrial cardiopathy is a proposed mechanism of embolic stroke of undetermined source (ESUS). Left atrial (LA) strain may identify early atrial cardiopathy prior to structural changes. We aim to study the associations between LA strain, ESUS, and atrial fibrillation (AF) detection in ESUS.
METHODS: The study population included patients with ESUS and noncardioembolic (NCE) stroke presenting to the Rhode Island Hospital Stroke Center between January 2016 and June 2017 who underwent transthoracic echocardiography. Speckle tracking echocardiography (STE) was used to measure the three phases of LA strain (reservoir, conduit, and contractile). Binary logistic regression analysis was performed to determine the associations between LA strain and stroke subtype (ESUS vs. NCE) as well as follow-up detection of AF in ESUS patients.
RESULTS: We identified 656 patients, 307 with ESUS and 349 with NCE. In binary logistic regression, the lowest tertiles of LA reservoir (adjusted OR 1.944, 95% CI 1.266-2.986, p = .002), contractile (aOR 1.568, 95% CI 1.035-2.374, p = .034), and conduit strain (aOR 2.288, 95% CI 1.448-3.613, p = .001) were more likely to be significantly associated with ESUS compared to NCE stroke. Among all ESUS patients, the lowest tertiles of LA reservoir strain (OR 2.534, 95% CI 1.029-6.236, p = .043), contractile strain (OR 2.828, 95% CI 1.158-6.903, p = .022), and conduit strain (OR 2.614, 95% CI 1.003-6.815, p = .049) were significantly associated with subsequent detection of AF.
CONCLUSIONS: Reduced LA strain is associated with ESUS occurrence and AF detection in ESUS patients. Therefore, quantification of LA strain in ESUS patients may improve risk stratification and guide secondary prevention strategies.