背景:阻力训练对肠衰竭(IF)患者肌肉减少症的潜在影响尚未完全阐明。本研究旨在探讨阻力训练计划对阑尾骨骼肌指数(ASMI)的疗效。物理性能,身体成分,生化参数,显示肌少症的IF患者的健康相关生活质量(HRQOL)。
方法:在中国某三级教学医院进行单中心随机对照试验。将显示肌肉减少症的IF患者随机分配到运动组或对照组。运动组的参与者进行了四组阻力训练,涉及四肢以及腹部和下背部肌肉,每周6次,共4周。对照组不接受具体干预。主要结果是干预后4周ASMI的组间差异。次要结果包括握力,6米的步态速度,身体成分,生化参数,HRQOL。
结果:共有60名参与者(对照组30,年龄51.2±12.9岁,女性43.3%;运动组30岁,年龄53.9±14.5岁,56.7%的女性)完成了为期4周的干预试验。对于主要结果,运动组和对照组的ASMI干预效果明显(平均差异0.72,95%CI,0.56-0.89,P<0.001)。握力存在显著差异(平均差异2.7,95%CI,1.7-3.6,P<0.001),6-m步态速度(平均差异0.08,95%CI,0.01-0.35,P=0.034),身体成分(包括总细胞质量,骨矿物质含量,骨骼肌质量,瘦质量,内脏脂肪面积,全身水,细胞内水,细胞外水,和分段水腿),和生化参数(包括IGF-1、前白蛋白、和血红蛋白)两组之间(P<0.05)。其他次要结局没有观察到显著的干预益处,包括生化参数(包括白蛋白,总胆红素,等。)和HRQOL(P>0.05)。
结论:在这项随机临床试验中,我们观察到4周的阻力训练与改善ASMI相关,物理性能,生化参数(包括IGF-1,前白蛋白,和血红蛋白),肌少症IF患者的身体成分。抗阻训练可作为改善IF患者肌少症的一种简单有效的方法。
背景:www.chictr.org.cn,标识符:ChiCTR2100051727。
The potential effects of resistance training on sarcopenia in patients with intestinal failure (IF) are not fully elucidated. This study aimed to explore the efficacy of a resistance training program on appendicular skeletal muscle index (ASMI), physical performance, body composition, biochemical parameters, and health-related quality of life (HRQOL) in patients with IF exhibiting sarcopenia.
A single-center randomized controlled trial was conducted in a Chinese tertiary teaching hospital. Patients with IF exhibiting sarcopenia were randomly assigned to the exercise group or control group. Participants in the exercise group incorporated four sets of resistance training involving the limbs and abdominal and lower back muscles, six times weekly for 4 weeks. The control group received no specific intervention. The primary outcome was the between-group difference in ASMI 4 weeks after intervention. Secondary outcomes included handgrip strength, 6-m gait speed, body composition, biochemical parameters, and HRQOL.
A total of 60 participants (control group 30, age 51.2 ± 12.9 years, women 43.3%; exercise group 30, age 53.9 ± 14.5 years, women 56.7%) completed the 4-week intervention trial. For the primary outcome, significant intervention effects were found in ASMI between the exercise group and the control group (mean difference 0.72, 95% CI, 0.56-0.89, P < 0.001). There were notable differences in handgrip strength (mean difference 2.7, 95% CI, 1.7-3.6, P < 0.001), 6-m gait speed (mean difference 0.08, 95% CI, 0.01-0.35, P = 0.034), body composition (including total cell mass, bone mineral content, skeletal muscle mass, lean mass, visceral fat area, total body water, intracellular water, extracellular water, and segmental water-legs), and biochemical parameters (including IGF-1, prealbumin, and hemoglobin) between the two groups (P < 0.05). No significant intervention benefits were observed for other secondary outcomes, including biochemical parameters (including albumin, total bilirubin, etc.) and HRQOL (P > 0.05).
In this randomized clinical trial, we observed that 4 weeks of resistance training was associated with improved ASMI, physical performance, biochemical parameters (including IGF-1, prealbumin, and hemoglobin), and body composition in IF patients with sarcopenia. Resistance training can be recommended as a simple and effective method to improve sarcopenia in patients with IF.
www.chictr.org.cn, identifier: ChiCTR2100051727.