■在肿瘤患者中,炎症,和血液疾病,高铁蛋白血症与基础疾病的严重程度相关,常伴有血小板计数低或血小板减少.尽管如此,尚未发现高铁蛋白血症和血小板计数之间存在明确的相关性.在这次回顾中,双中心研究,我们试图描述高铁蛋白血症患者血小板减少的患病率和严重程度.
■本研究共纳入901个样本,在2019年1月至2021年6月期间,所有这些患者的铁蛋白水平均显着较高(>2000μg/L)。我们分析了总分布,高铁蛋白血症患者血小板减少症的发生率,以及铁蛋白水平与血小板计数的关系。P值<0.05被认为是统计学上显著的。
■高铁蛋白血症患者血小板减少的总发生率为64.7%。血液系统疾病是高铁蛋白血症的最常见原因(43.1%),其次是实体瘤(29.5%)和感染性疾病(11.7%)。血小板减少症(<150×109/L)患者的铁蛋白水平明显高于血小板计数超过150×109/L的患者,铁蛋白中位数水平为4011和3221μg/L,分别(P<0.001)。此外,结果显示,慢性输血的血液学患者的血小板减少发生率高于无慢性输血的患者(93%vs69%)。
■总而言之,我们的研究结果提示血液系统疾病是高铁蛋白血症的最常见原因,而慢性输血患者更容易发生血小板减少.铁蛋白水平升高可能是血小板减少症的触发因素。
UNASSIGNED: In patients with tumors, inflammation, and blood disorders,
hyperferritinemia has been associated with the severity of the underlying disease and is frequently accompanied by a co-occurring low platelet count or thrombocytopenia. Despite this, no established correlation has been identified between
hyperferritinemia and platelet count. In this retrospective, double-center study, we sought to describe the prevalence and severity of thrombocytopenia in patients with hyperferritinemia.
UNASSIGNED: A total of 901 samples were enrolled in this study, all of which had significantly high ferritin levels (>2000 μg/L) between January 2019 and June 2021. We analyzed the general distribution, incidence of thrombocytopenia in patients with
hyperferritinemia, and the relationship between ferritin level and platelet count. p-values < 0.05 were considered statistically significant.
UNASSIGNED: The total incidence of thrombocytopenia in patients with
hyperferritinemia was 64.7%. Hematological diseases were the most frequent cause of
hyperferritinemia (43.1%), followed by solid tumors (29.5%) and infectious diseases (11.7%). Patients with thrombocytopenia (<150 × 109/L) had significantly higher ferritin levels than those with platelet counts exceeding 150 × 109/L, with median ferritin levels of 4011 and 3221 μg/L, respectively (P < 0.001). Additionally, the results showed that the incidence of thrombocytopenia was higher in hematological patients with chronic transfusion than in those without chronic blood transfusions (93% vs 69%).
UNASSIGNED: In conclusion, our results suggest that hematological diseases are the most common cause of hyperferritinemia and that patients with chronic blood transfusions are more susceptible to thrombocytopenia. Elevated ferritin levels may act as a trigger for thrombocytopenia.