溶血性尿毒症综合征(HUS)是一种严重的综合征,给患者及其家庭带来沉重负担,是儿童急性肾损伤的主要原因。然而,亚洲HUS的流行病学和疾病负担数据,包括中国,是有限的。我们的目的是估计HUS在中国的发病率和成本。方法:从城镇职工基本医疗保险(UEBMI)和城镇居民基本医疗保险(URBMI)数据库中提取2012-2016年HUS数据。所有病例均通过ICD编码和中文诊断术语进行识别。2016年全国发病率按性别进行了估计和分层,年龄和季节。还计算了相关的医疗费用。
HUS的粗发生率为每100,000人年0.66(95%CI:0.35至1.06),标准化发生率为0.57(0.19至1.18)。男性HUS的发病率略高于女性。HUS发生率最高的年龄组为<1岁患者(5.08,95%CI:0.23~24.87),发病率最高的季节是秋天,其次是冬天。HUS的平均费用为每名患者21.5万美元,高于同期所有住院患者的全国平均费用。
这是关于中国城市HUS发病率的首次基于人群的研究。中国城市HUS的年龄和季节分布与大多数发达国家不同,提示病因的差异。
Haemolytic uraemic syndrome (HUS) is a severe syndrome that causes a substantial burden for patients and their families and is the leading cause of acute kidney injury in children. However, data on the epidemiology and disease burden of HUS in Asia, including
China, are limited. We aimed to estimate the incidence and cost of HUS in
China. METHODS: Data about HUS from 2012 to 2016 were extracted from the Urban Employee Basic Medical Insurance (UEBMI) and Urban Resident Basic Medical Insurance (URBMI) databases. All cases were identified by ICD code and Chinese diagnostic terms. The 2016 national incidence rates were estimated and stratified by sex, age and season. The associated medical costs were also calculated.
The crude incidence of HUS was 0.66 per 100,000 person-years (95% CI: 0.35 to 1.06), and the standardized incidence was 0.57 (0.19 to 1.18). The incidence of HUS in males was slightly higher than that in females. The age group with the highest incidence of HUS was patients < 1 year old (5.08, 95% CI: 0.23 to 24.87), and the season with the highest incidence was autumn, followed by winter. The average cost of HUS was 2.15 thousand US dollars per patient, which was higher than the national average cost for all inpatients in the same period.
This is the first population-based study on the incidence of HUS in urban
China. The age and seasonal distributions of HUS in urban
China are different from those in most developed countries, suggesting a difference in aetiology.