冠状病毒（CoV），一个有包膜的正义RNA病毒家族，其特征是从其表面突出的棍棒状尖刺，异常大的RNA基因组，和独特的复制能力。已知CoV会导致各种潜在致命的人类呼吸道传染病，如严重急性呼吸系统综合症（SARS），中东呼吸综合征（MERS）以及最近的2019年冠状病毒病（COVID-19）爆发。不幸的是,迄今为止，尚未批准药物和疫苗来预防和治疗由CoV引起的这些疾病。因此,迫切需要有效的预防和治疗人类冠状病毒的药物。在过去的几十年里，据报道，许多天然化合物具有多种生物活性，包括抗病毒特性。在这篇文章中,我们对干扰SARS和MERS生命周期的天然化合物进行了全面审查，并讨论了它们在治疗COVID-19中的潜在用途。
Coronaviruses (CoVs), a family of enveloped positive-sense RNA viruses, are characterized by club-like spikes that project from their surface, unusually large RNA genome, and unique replication capability. CoVs are known to cause various potentially lethal human respiratory infectious diseases, such as severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), and the very recent coronavirus disease 2019 (COVID-19) outbreak. Unfortunately, neither drug nor vaccine has yet been approved to date to prevent and treat these diseases caused by CoVs. Therefore, effective prevention and treatment medications against human coronavirus are in urgent need. In the past decades, many natural compounds have been reported to possess multiple biological activities, including antiviral properties. In this article, we provided a comprehensive review on the natural compounds that interfere with the life cycles of SARS and MERS, and discussed their potential use for the treatment of COVID-19.
PDF(Sci-hub)