背景:基于传感器的步态分析为评估帕金森病(PD)中的步态损伤及其相关因素提供了可靠的定量工具。临床上观察到焦虑会干扰步态,但调查不充分。我们的目的是利用步态分析来揭示焦虑对PD患者步态的影响。
方法:我们招募了38名和106名患有和不患有焦虑症的PD患者,分别。在单任务(ST)和双任务(DT)步行测试中,对步态参数进行了定量检查并比较。多元线性回归用于评估焦虑是否独立地导致步态障碍。
结果:在ST期间,患有焦虑症的PD患者的步幅明显较短,较低的步态速度,更长的跨步时间和站立时间,更长的站立阶段,比没有焦虑的人更小的脚趾离地(TO)和脚跟撞击(HS)角度。在DT状态下,差异缩小了。多元线性回归分析表明,焦虑是一系列步态参数的独立因素,特别是ST-TO(B=-2.599,(-4.82,-0.38)),ST-HS(B=-2.532,(-4.71,-0.35)),ST-TO-CV(B=4.627,(1.71,7.64)),ST-HS-CV(B=4.597,(1.66,7.53)),ST站姿阶段(B=1.4,(0.22,2.58)),和DT站位阶段(B=1.749,(0.56,2.94))。
结论:我们的研究发现,焦虑对PD患者的步态障碍有显著影响,尤其是加重改组步骤和延长站立阶段。这些发现强调了在PD精确治疗中解决焦虑以实现更好治疗结果的重要性。
BACKGROUND: Sensor-based gait analysis provides a robust quantitative tool for assessing gait impairments and their associated factors in Parkinson\'s disease (PD). Anxiety is observed to interfere with gait clinically, but this has been poorly investigated. Our purpose is to utilize gait analysis to uncover the effect of anxiety on gait in patients with PD.
METHODS: We enrolled 38 and 106 PD patients with and without anxiety, respectively. Gait parameters were quantitively examined and compared between two groups both in single-task (ST) and dual-task (DT) walking tests. Multiple linear regression was applied to evaluate whether anxiety independently contributed to gait impairments.
RESULTS: During ST, PD patients with anxiety presented significantly shorter stride length, lower gait velocity, longer stride time and stance time, longer stance phase, smaller toe-off (TO) and heel-strike (HS) angles than those without anxiety. While under DT status, the differences were diminished. Multiple linear regression analysis demonstrated that anxiety was an independent factor to a serials of gait parameters, particularly ST-TO (B = -2.599, (-4.82, -0.38)), ST-HS (B = -2.532, (-4.71, -0.35)), ST-TO-CV (B = 4.627, (1.71, 7.64)), ST-HS-CV(B = 4.597, (1.66, 7.53)), ST stance phase (B = 1.4, (0.22, 2.58)), and DT stance phase (B = 1.749, (0.56, 2.94)).
CONCLUSIONS: Our study discovered that anxiety has a significant impact on gait impairments in PD patients, especially exacerbating shuffling steps and prolonging stance phase. These findings highlight the importance of addressing anxiety in PD precision therapy to achieve better treatment outcomes.